User profiles for Bart Tarbet
 | Bart TarbetUtah State University Verified email at usu.edu Cited by 3117 |
[HTML][HTML] Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease
A new coronavirus SARS-CoV-2, also called novel coronavirus 2019 (2019-nCoV), started
to circulate among humans around December 2019, and it is now widespread as a global …
to circulate among humans around December 2019, and it is now widespread as a global …
Structure and inhibition of the SARS-CoV-2 main protease reveal strategy for developing dual inhibitors against Mpro and cathepsin L
The main protease (M pro ) of SARS-CoV-2 is a key antiviral drug target. While most M pro
inhibitors have a γ-lactam glutamine surrogate at the P1 position, we recently found that …
inhibitors have a γ-lactam glutamine surrogate at the P1 position, we recently found that …
Boceprevir, calpain inhibitors II and XII, and GC-376 have broad-spectrum antiviral activity against coronaviruses
As the COVID-19 pandemic continues to unfold, the morbidity and mortality are increasing
daily. Effective treatment for SARS-CoV-2 is urgently needed. We recently discovered four …
daily. Effective treatment for SARS-CoV-2 is urgently needed. We recently discovered four …
[HTML][HTML] Immunogenicity and efficacy of flagellin-fused vaccine candidates targeting 2009 pandemic H1N1 influenza in mice
G Liu, B Tarbet, L Song, L Reiserova, B Weaver… - PloS one, 2011 - journals.plos.org
We have previously demonstrated that the globular head of the hemagglutinin (HA) antigen
fused to flagellin of Salmonella typhimurium fljB (STF2, a TLR5 ligand) elicits protective …
fused to flagellin of Salmonella typhimurium fljB (STF2, a TLR5 ligand) elicits protective …
Efficacy of an isoxazole-3-carboxamide analog of pleconaril in mouse models of Enterovirus-D68 and Coxsackie B5
TR Lane, J Fu, B Sherry, B Tarbet, BL Hurst… - Antiviral Research, 2023 - Elsevier
Enteroviruses (EV) cause a number of life-threatening infectious diseases. EV-D68 is known
to cause respiratory illness in children that can lead to acute flaccid myelitis. Coxsackievirus …
to cause respiratory illness in children that can lead to acute flaccid myelitis. Coxsackievirus …
Rational design of a new class of protease inhibitors for the potential treatment of coronavirus diseases
The coronavirus main protease, M pro , is a key protein in the virus life cycle and a major
drug target. Based on crystal structures of SARSCoV2 M pro complexed with peptidomimetic …
drug target. Based on crystal structures of SARSCoV2 M pro complexed with peptidomimetic …
Consensus M2e peptide conjugated to gold nanoparticles confers protection against H1N1, H3N2 and H5N1 influenza A viruses
The extracellular domain of influenza A ion channel membrane matrix protein 2 (M2e) is
considered to be a potential candidate to develop a universal influenza A vaccine. However …
considered to be a potential candidate to develop a universal influenza A vaccine. However …
[PDF][PDF] Engineering a therapeutic lectin by uncoupling mitogenicity from antiviral activity
A key effector route of the Sugar Code involves lectins that exert crucial regulatory controls
by targeting distinct cellular glycans. We demonstrate that a single amino-acid substitution in …
by targeting distinct cellular glycans. We demonstrate that a single amino-acid substitution in …
Effects of the combination of favipiravir (T-705) and oseltamivir on influenza A virus infections in mice
…, MH Wong, KW Bailey, EB Tarbet… - Antimicrobial agents …, 2010 - Am Soc Microbiol
Favipiravir (T-705 [6-fluoro-3-hydroxy-2-pyrazinecarboxamide]) and oseltamivir were
combined to treat influenza virus A/NWS/33 (H1N1), A/Victoria/3/75 (H3N2), and A/Duck/MN/1525/…
combined to treat influenza virus A/NWS/33 (H1N1), A/Victoria/3/75 (H3N2), and A/Duck/MN/1525/…
A molecularly engineered antiviral banana lectin inhibits fusion and is efficacious against influenza virus infection in vivo
There is a strong need for a new broad-spectrum antiinfluenza therapeutic, as vaccination
and existing treatments are only moderately effective. We previously engineered a lectin, …
and existing treatments are only moderately effective. We previously engineered a lectin, …