E2F transcription factors are known to be important for timely activation of G 1 /S and G 2 /M
genes required for cell cycle progression, but transcriptional mechanisms for deactivation of …

Programmed polyploidization occurs in all mammalian species during development and
aging in selected tissues, but the biological properties of polyploid cells remain obscure. …

The atypical E2Fs, E2F7 and E2F8, act as potent transcriptional repressors of DNA replication
genes providing them with the ability to induce a permanent S‐phase arrest and suppress …

E2F transcription factors control the cytokinesis machinery and thereby ploidy in hepatocytes.
If or how these proteins limit proliferation of polyploid cells with extra centrosomes remains …

E2F transcription factors control the expression of cell-cycle genes. Cancers often
demonstrate enhanced E2F target gene expression, which can be explained by increased …

Polyploidization is observed in all mammalian species and is a characteristic feature of
hepatocytes, but its molecular mechanism and biological significance are unknown. Hepatocyte …

The E2F family of transcription factors plays an important role in controlling cell‐cycle
progression. While this is their best‐known function, we report here novel functions for the newest …

Disruption of the retinoblastoma (RB) tumor suppressor pathway, either through genetic
mutation of upstream regulatory components or mutation of RB1 itself, is believed to be a …

E2F-mediated transcriptional repression of cell cycle–dependent gene expression is critical
for the control of cellular proliferation, survival, and development. E2F signaling also …

E2F7 and E2F8 act as tumor suppressors via transcriptional repression of genes involved in
S‐phase entry and progression. Previously, we demonstrated that these atypical E2Fs are …