During aging, progenitor cells acquire mutations, which may generate clones that colonize
the surrounding tissue. By middle age, normal human tissues, including the esophageal …

The effect of gender and caloric restriction on mitochondrial content and oxidative-phosphorylative
capacities has been investigated in rat gastrocnemius muscle. Muscle protein, …

The migration of neutrophils into inflamed tissues is a fundamental component of innate
immunity. A decisive step in this process is the polarized migration of blood neutrophils through …

Breaching endothelial cells (ECs) is a decisive step in the migration of leukocytes from the
vascular lumen to the extravascular tissue, but fundamental aspects of this response remain …

Endothelial cells line the lumen of all blood vessels and play a critical role in maintaining the
barrier function of the vasculature. Sealing of the vessel wall between adjacent endothelial …

Objective: Gender and diet have an important effect in cardiovascular disease and other
aging-associated disorders, whose initiation and/or worsening seem to be delayed in females …

Endogenous protective pathways mitigate the overshooting of inflammation after sterile or
infectious injury. Here we report that formyl peptide receptor 2 (Fpr2/3) null mice display a …

In adult skin epidermis and the epithelium lining the esophagus cells are constantly shed
from the tissue surface and replaced by cell division. Tracking genetically labelled cells in …

Objective— Junctional adhesion molecule-C (JAM-C) is an adhesion molecule that has
multiple roles in inflammation and vascular biology, but many aspects of its functions under …

Anti-MDA5 antibodies have been strongly associated with rapidly progressive interstitial lung
disease (RP-ILD) in dermatomyositis (DM) patients, especially in the clinically amyopathic …