Endoplasmic reticulum (ER) stress is observed in many human diseases, often associated
with inflammation. ER stress can trigger inflammation through nucleotide-binding domain and …

Vibrio cholerae is a gram-negative bacterium that is the causative agent of cholera, a severe
diarrheal illness. The two biotypes of V. cholerae O1 capable of causing cholera, classical …

Pathogenic bacteria taken up into the macrophage phagosome are the target of many anti-microbial
mechanisms. Although mitochondria-derived antimicrobial effectors like reactive …

The human diarrheal disease cholera is caused by the aquatic bacterium Vibrio cholerae . V.
cholerae in the environment is associated with several varieties of aquatic life, including …

Neutrophils amplify inflammation in lupus through the release of neutrophil extracellular
traps (NETs). The endoplasmic reticulum stress sensor inositol-requiring enzyme 1 α (IRE1α) …

Macrophage metabolic plasticity enables repurposing of electron transport from energy
generation to inflammation and host defense. Altered respiratory complex II function has been …

The mitochondrial network plays a critical role in the regulation of innate immune signaling
and subsequent production of proinflammatory cytokines such as IFN-β and IL-1β. Dynamin-…

Bacterial infection can trigger cellular stress programs, such as the unfolded protein
response (UPR), which occurs when misfolded proteins accumulate within the endoplasmic …

Infection of the human gut by Salmonella enterica Typhimurium (STM) results in a localized
inflammatory disease that is not mimicked in murine infections. To determine mechanisms by …

Immune cells must be able to adjust their metabolic programs to effectively carry out their
effector functions. Here, we show that the endoplasmic reticulum (ER) stress sensor Inositol-…