[HTML][HTML] Effects of race and ethnicity on perinatal outcomes in high-income and upper-middle-income countries: an individual participant data meta-analysis of 2 198 …

…, L McCowan, E Pajkrt, BG Haddad, G Dekker… - The Lancet, 2022 - thelancet.com
Background Existing evidence on the effects of race and ethnicity on pregnancy outcomes is
restricted to individual studies done within specific countries and health systems. We aimed …

Structure of native lens connexin 46/50 intercellular channels by cryo-EM

JB Myers, BG Haddad, SE O'Neill, DS Chorev… - Nature, 2018 - nature.com
Gap junctions establish direct pathways for cell-to-cell communication through the assembly
of twelve connexin subunits that form intercellular channels connecting neighbouring cells. …

[HTML][HTML] Connexin-46/50 in a dynamic lipid environment resolved by CryoEM at 1.9 Å

JA Flores, BG Haddad, KA Dolan, JB Myers… - Nature …, 2020 - nature.com
Gap junctions establish direct pathways for cells to transfer metabolic and electrical messages.
The local lipid environment is known to affect the structure, stability and intercellular …

[HTML][HTML] Elevator-like movements of prestin mediate outer hair cell electromotility

MF Kuwabara, BG Haddad, D Lenz-Schwab… - Nature …, 2023 - nature.com
The outstanding acuity of the mammalian ear relies on cochlear amplification, an active
mechanism based on the electromotility (eM) of outer hair cells. eM is a piezoelectric mechanism …

Connexin 46 and connexin 50 gap junction channel properties are shaped by structural and dynamic features of their N‐terminal domains

B Yue, BG Haddad, U Khan, H Chen… - The Journal of …, 2021 - Wiley Online Library
Key points Gap junctions formed by different connexins are expressed throughout the body
and harbour unique channel properties that have not been fully defined mechanistically. …

Ribosomal protein L7/L12 is required for GTP ase translation factors EF‐G, RF 3, and IF 2 to bind in their GTP state to 70S ribosomes

MA Carlson, BG Haddad, AJ Weis… - The FEBS …, 2017 - Wiley Online Library
Ribosomal protein L7/L12 is associated with translation initiation, elongation, and termination
by the 70S ribosome. The guanosine 5′ triphosphate hydrolase ( GTP ase) activity of …

External validation of prognostic models to predict stillbirth using International Prediction of Pregnancy Complications (IPPIC) Network database: individual participant …

…, HJ Teede, BG Haddad, G Dekker… - … in Obstetrics & …, 2022 - Wiley Online Library
Objective Stillbirth is a potentially preventable complication of pregnancy. Identifying women
at high risk of stillbirth can guide decisions on the need for closer surveillance and timing of …

[PDF][PDF] Molecular mechanisms underlying enhanced hemichannel function of a cataract-associated Cx50 mutant

JJ Tong, U Khan, BG Haddad, PJ Minogue, EC Beyer… - Biophysical …, 2021 - cell.com
Connexin-50 (Cx50) is among the most frequently mutated genes associated with congenital
cataracts. Although most of these disease-linked variants cause loss of function because of …

[HTML][HTML] Diclofenac and other non-steroidal anti-inflammatory drugs (NSAIDs) are competitive antagonists of the human P2X3 receptor

L Grohs, L Cheng, S Cönen, BG Haddad… - Frontiers in …, 2023 - frontiersin.org
Introduction: The P2X3 receptor (P2X3R), an ATP-gated non-selective cation channel of the
P2X receptor family, is expressed in sensory neurons and involved in nociception. P2X3R …

[HTML][HTML] A novel homozygous KLHL3 mutation as a cause of autosomal recessive pseudohypoaldosteronism type II diagnosed late in life

A Etges, N Hellmig, G Walenda, BG Haddad… - Nephron, 2022 - karger.com
Introduction: Pseudohypoaldosteronism type II (PHA II) is a Mendelian disorder, featuring
hyperkalemic acidosis and low plasma renin levels, typically associated with hypertension. …