[HTML][HTML] Effects of race and ethnicity on perinatal outcomes in high-income and upper-middle-income countries: an individual participant data meta-analysis of 2 198 …
…, L McCowan, E Pajkrt, BG Haddad, G Dekker… - The Lancet, 2022 - thelancet.com
Background Existing evidence on the effects of race and ethnicity on pregnancy outcomes is
restricted to individual studies done within specific countries and health systems. We aimed …
restricted to individual studies done within specific countries and health systems. We aimed …
Structure of native lens connexin 46/50 intercellular channels by cryo-EM
JB Myers, BG Haddad, SE O'Neill, DS Chorev… - Nature, 2018 - nature.com
Gap junctions establish direct pathways for cell-to-cell communication through the assembly
of twelve connexin subunits that form intercellular channels connecting neighbouring cells. …
of twelve connexin subunits that form intercellular channels connecting neighbouring cells. …
[HTML][HTML] Connexin-46/50 in a dynamic lipid environment resolved by CryoEM at 1.9 Å
Gap junctions establish direct pathways for cells to transfer metabolic and electrical messages.
The local lipid environment is known to affect the structure, stability and intercellular …
The local lipid environment is known to affect the structure, stability and intercellular …
[HTML][HTML] Elevator-like movements of prestin mediate outer hair cell electromotility
MF Kuwabara, BG Haddad, D Lenz-Schwab… - Nature …, 2023 - nature.com
The outstanding acuity of the mammalian ear relies on cochlear amplification, an active
mechanism based on the electromotility (eM) of outer hair cells. eM is a piezoelectric mechanism …
mechanism based on the electromotility (eM) of outer hair cells. eM is a piezoelectric mechanism …
Connexin 46 and connexin 50 gap junction channel properties are shaped by structural and dynamic features of their N‐terminal domains
Key points Gap junctions formed by different connexins are expressed throughout the body
and harbour unique channel properties that have not been fully defined mechanistically. …
and harbour unique channel properties that have not been fully defined mechanistically. …
Ribosomal protein L7/L12 is required for GTP ase translation factors EF‐G, RF 3, and IF 2 to bind in their GTP state to 70S ribosomes
MA Carlson, BG Haddad, AJ Weis… - The FEBS …, 2017 - Wiley Online Library
Ribosomal protein L7/L12 is associated with translation initiation, elongation, and termination
by the 70S ribosome. The guanosine 5′ triphosphate hydrolase ( GTP ase) activity of …
by the 70S ribosome. The guanosine 5′ triphosphate hydrolase ( GTP ase) activity of …
External validation of prognostic models to predict stillbirth using International Prediction of Pregnancy Complications (IPPIC) Network database: individual participant …
Objective Stillbirth is a potentially preventable complication of pregnancy. Identifying women
at high risk of stillbirth can guide decisions on the need for closer surveillance and timing of …
at high risk of stillbirth can guide decisions on the need for closer surveillance and timing of …
[PDF][PDF] Molecular mechanisms underlying enhanced hemichannel function of a cataract-associated Cx50 mutant
Connexin-50 (Cx50) is among the most frequently mutated genes associated with congenital
cataracts. Although most of these disease-linked variants cause loss of function because of …
cataracts. Although most of these disease-linked variants cause loss of function because of …
[HTML][HTML] Diclofenac and other non-steroidal anti-inflammatory drugs (NSAIDs) are competitive antagonists of the human P2X3 receptor
L Grohs, L Cheng, S Cönen, BG Haddad… - Frontiers in …, 2023 - frontiersin.org
Introduction: The P2X3 receptor (P2X3R), an ATP-gated non-selective cation channel of the
P2X receptor family, is expressed in sensory neurons and involved in nociception. P2X3R …
P2X receptor family, is expressed in sensory neurons and involved in nociception. P2X3R …
[HTML][HTML] A novel homozygous KLHL3 mutation as a cause of autosomal recessive pseudohypoaldosteronism type II diagnosed late in life
A Etges, N Hellmig, G Walenda, BG Haddad… - Nephron, 2022 - karger.com
Introduction: Pseudohypoaldosteronism type II (PHA II) is a Mendelian disorder, featuring
hyperkalemic acidosis and low plasma renin levels, typically associated with hypertension. …
hyperkalemic acidosis and low plasma renin levels, typically associated with hypertension. …