Contractile injection systems (CIS) are bacteriophage tail-like structures that mediate
bacterial cell–cell interactions. While CIS are highly abundant across diverse bacterial phyla, …

Gram-negative bacteria use type IV secretion systems (T4SSs) for a variety of macromolecular
transport processes that include the exchange of genetic material. The pKM101 plasmid …

Type IV secretion systems are multiprotein complexes that mediate the translocation of
macromolecules across the bacterial cell envelope. In Helicobacter pylori a type IV secretion …

The increasing frequency of antimicrobial resistance is a problem of global importance.
Novel strategies are urgently needed to understand and inhibit antimicrobial resistance gene …

In mammalian cells, the incorporation of the 21st amino acid, selenocysteine, into proteins
is guided by the Sec machinery. The function of this protein complex requires several protein–…

Type IV secretion systems (T4SSs) are multiprotein assemblies that translocate macromolecules
across the cell envelope of bacteria. X-ray crystallographic and electron microscopy (EM…

The acquisition of multidrug resistance (MDR) determinants jeopardizes treatment of bacterial
infections with antibiotics. The tripartite efflux pump AcrAB-NodT confers adaptive MDR in …

We here describe the structure-based design of small molecule inhibitors of the type IV
secretion system of Helicobacter pylori. The secretion system is encoded by the cag …

Contractile injection systems (CISs) are bacteriophage tail-like structures that mediate
bacterial cell-cell interactions. While CISs are highly abundant across diverse bacterial phyla, …

Helicobacter pylori is an important cause of gastric pathologies and persistent infection can
lead to stomach cancer. Virulent H. pylori strains encode a type IV secretion system …