Recent advances in structural, biochemical, biophysical, and live cell imaging approaches
have furthered our understanding of the molecular mechanisms by which regulated assembly …

WASP-homology 2 (WH2) domains, which were first identified in the WASP/Scar (suppressor
of cAMP receptor)/WAVE (WASP-family verprolin homologous protein) family of proteins, …

The members of the formin family nucleate actin polymerization and play essential roles in
the regulation of the actin cytoskeleton during a wide range of cellular and developmental …

Directed axonal growth depends on correct coordination of the actin and microtubule
cytoskeleton in the growth cone. However, despite the relatively large number of proteins …

We characterized the properties of Drosophila melanogaster DAAM-FH2 and DAAM-FH1-FH2
fragments and their interactions with actin and profilin by using various biophysical …

Formins bind actin filaments and play an essential role in the regulation of the actin cytoskeleton.
In this work we describe details of the formin-induced conformational changes in actin …

Diaphanous-related formins (Drf) are activated by Rho GTP binding proteins and induce
polymerization of unbranched actin filaments. They contain three formin homology domains. …

At the leading edge of migrating cells, protrusive forces are developed by the assembly of
actin filaments organised in a lamellipodial dendritic array at the front and a more distal …

Actin is a protein abundant in many cell types. Decades of investigations have provided
evidence that it has many functions in living cells. The diverse morphology and dynamics of actin …

During muscle development, myosin and actin containing filaments assemble into the highly
organized sarcomeric structure critical for muscle function. Although sarcomerogenesis …