The Down syndrome (DS) phenotype is usually characterized by relative strengths in non-verbal
skills and deficits in verbal processing, but high interindividual variability has been …

Background Trisomy 21 (T21) is a genetic alteration characterised by the presence of an
extra full or partial human chromosome 21 (Hsa21) leading to Down syndrome (DS), the most …

This work investigates the role of metabolite levels in the intellectual impairment of subjects
with Down syndrome (DS). Homocysteine, folate, vitamin B12, uric acid (UA), creatinine …

Down syndrome (DS) is caused by trisomy of chromosome 21 and it is the most common
genetic cause of intellectual disability (ID) in humans. Subjects with DS show a typical …

Down syndrome (DS) is characterised by several clinical features including intellectual
disability (ID) and craniofacial dysmorphisms. In 1976, Jackson and coll. identified a checklist of …

Down syndrome (DS) is the most common chromosomal disorder and it is caused by trisomy
of chromosome 21 (Hsa21). Subjects with DS show a large heterogeneity of phenotypes …

Introduction Trisomy 21 (T21), which causes Down syndrome (DS), is the most common
chromosomal aneuploidy in humankind and includes different clinical comorbidities, among …

Background Down syndrome (DS) is caused by the presence of an extra copy of full or partial
human chromosome 21 (Hsa21). Partial (segmental) trisomy 21 (PT21) is the duplication …

The one‐carbon metabolism pathway is involved in critical human cellular functions such as
cell proliferation, mitochondrial respiration, and epigenetic regulation. In the homocysteine‐…

Background Persons with Down syndrome (DS) reveal adaptive functioning (AF) difficulties.
Studies on AF in DS have focused mainly on describing the profile (ie, strengths in …