Riboswitches are newly discovered regulatory elements which control a wide set of basic
metabolic pathways. They consist solely of RNA, sense their ligand in a preformed binding …

We present a conditional gene expression system in Saccharomyces cerevisiae which
exploits direct RNA–metabolite interactions as a mechanism of genetic control. We inserted …

Highlights • Addition of in vivo active aptamer domains for DNT and PPDA to the toolbox. •
Addition of expression platforms for transcriptional termination to the toolbox. • Modular ‘plug-…

RNA utilizes many different mechanisms to control gene expression. Among the regulatory
elements that respond to external stimuli, riboswitches are a prominent and elegant example. …

Riboswitches are genetic control elements that regulate gene expression in a small
molecule-dependent way. We developed a two-stage strategy of in vitro selection followed by a …

Riboswitches are natural RNA-based genetic switches that sense small-molecule metabolites
and regulate in response the expression of the corresponding metabolic genes. Within the …

Riboswitches reflect a novel concept in gene regulation that is particularly suited for
technological adaptation. Therefore, we characterized thermodynamically the ligand binding …

Splicing of pre-mRNA is a critical step in mRNA maturation and disturbances cause several
genetic disorders. We apply the synthetic tetracycline (tc)-binding riboswitch to establish a …

We describe post‐transcriptional gene regulation in yeast based on direct RNA–ligand
interaction. Tetracycline‐dependent translational regulation could be imposed via specific …

Cyclooxygenase (COX)-2–derived prostanoids can influence several processes that are
linked to carcinogenesis. We aimed to address the hypothesis that platelets contribute to …