Despite a century of research on complex traits in humans, the relative importance and specific
nature of the influences of genes and environment on human traits remain controversial. …

SNPs discovered by genome-wide association studies (GWASs) account for only a small
fraction of the genetic variation of complex traits in human populations. Where is the remaining …

Schizophrenia is a debilitating psychiatric disorder with approximately 1% lifetime risk globally.
Large-scale schizophrenia genetic studies have reported primarily on European ancestry …

We report a genome-wide association study to iron status. We identify an association of SNPs
in TPMRSS6 to serum iron (rs855791, combined P = 1.5 × 10 −20 ), transferrin saturation (…

Schizophrenia has a heritability of 60–80% 1 , much of which is attributable to common risk
alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with …

We identify common genetic variants associated with cognitive performance using a two-stage
approach, which we call the proxy-phenotype method. First, we conduct a genome-wide …

Cross-ethnic genetic studies can leverage power from differences in disease epidemiology
and population-specific genetic architecture. In particular, the differences in linkage …

We develop a novel approach to identify regions of the genome underlying population genetic
differentiation in any genetic data where the underlying population structure is unknown, …

Anaemia is a chief determinant of global ill health, contributing to cognitive impairment,
growth retardation and impaired physical capacity. To understand further the genetic factors …

Intelligence in childhood, as measured by psychometric cognitive tests, is a strong predictor
of many important life outcomes, including educational attainment, income, health and …