Ascending dopaminergic projections from neurons located in the Ventral Tegmental Area (VTA)
are key to the etiology, dysfunction, and control of motivation, learning, and addiction. …

Only 200 years ago, virtually nothing was known about the biological workings of the mind.
Today, there is a deep (though far from complete) understanding of the cellular and …

LabbookDB is a relational database application framework for life sciences—providing an
extendable schema and functions to conveniently add and retrieve information, and generate …

The serotonergic system is widely implicated in affect regulation, and a common target for
psychopharmacological interventions. Selective Serotonin Reuptake Inhibitors (SSRIs) are the …

Ascending dopaminergic projections from neurons located in the Ventral Tegmental Area (VTA)
are key to the etiology, dysfunction, and control of motivation, learning, and addiction. …

The molecular underpinnings of exploration and its link to learning and memory remain
poorly understood. Here we show that inducible, modest overexpression of neuronal calcium …

The intracellular signaling targets used by mammalian axon guidance receptors to organize
the nervous system in vivo are unclear. The Nck1 and Nck2 SH2/SH3 adaptors (collectively …

In a mouse mutagenesis screen, we isolated a mutant, Myshkin (Myk), with autosomal
dominant complex partial and secondarily generalized seizures, a greatly reduced threshold for …

Background The ascending serotonergic system is of great clinical importance due to its
implication in affective disorders and their treatment. The origin of the majority of ascending …

Background Memory blockade is an essential component of the anesthetic state. However,
postanesthesia memory deficits represent an undesirable and poorly understood adverse …