Cerebellar output controls generalized spike‐and‐wave discharge occurrence
Objective Disrupting thalamocortical activity patterns has proven to be a promising approach
to stop generalized spike‐and‐wave discharges (GSWDs) characteristic of absence …
to stop generalized spike‐and‐wave discharges (GSWDs) characteristic of absence …
Purkinje cells in awake behaving animals operate at the upstate membrane potential
M Schonewille, S Khosrovani, BHJ Winkelman… - Nature …, 2006 - nature.com
Over the last decades, cellular bistability or multistable states of the membrane potential
have been demonstrated both in vitro and in vivo for different types of neurons throughout the …
have been demonstrated both in vitro and in vivo for different types of neurons throughout the …
[HTML][HTML] Age-and sex-related differences in contrast sensitivity in C57BL/6 mice
B van Alphen, BHJ Winkelman… - … ophthalmology & visual …, 2009 - iovs.arvojournals.org
purpose. To measure contrast sensitivity in C57BL/6, the most commonly used mouse in
behavioral neuroscience, and to study the effect of sex, age, and miotic drugs on the contrast …
behavioral neuroscience, and to study the effect of sex, age, and miotic drugs on the contrast …
[HTML][HTML] Loss of Gap Junction Delta-2 (GJD2) gene orthologs leads to refractive error in zebrafish
…, RM Lukowicz, S Broekman, BHJ Winkelman… - Communications …, 2021 - nature.com
Myopia is the most common developmental disorder of juvenile eyes, and it has become an
increasing cause of severe visual impairment. The GJD2 locus has been consistently …
increasing cause of severe visual impairment. The GJD2 locus has been consistently …
[HTML][HTML] Vestibular role of KCNQ4 and KCNQ5 K+ channels revealed by mouse models
G Spitzmaul, L Tolosa, BHJ Winkelman… - Journal of Biological …, 2013 - ASBMB
The function of sensory hair cells of the cochlea and vestibular organs depends on an influx
of K + through apical mechanosensitive ion channels and its subsequent removal over their …
of K + through apical mechanosensitive ion channels and its subsequent removal over their …
[HTML][HTML] Three-dimensional optokinetic eye movements in the C57BL/6J mouse
B van Alphen, BHJ Winkelman… - … ophthalmology & visual …, 2010 - jov.arvojournals.org
Purpose.: To study three-dimensional optokinetic eye movements of wild-type C57BL/6J
mice, the most commonly used mouse in oculomotor physiology. Optokinetic eye movements …
mice, the most commonly used mouse in oculomotor physiology. Optokinetic eye movements …
ACTA2 mutation with childhood cardiovascular, autonomic and brain anomalies and severe outcome
…, Y van Bever, BHJ Winkelman… - American Journal of …, 2013 - Wiley Online Library
Thoracic aortic aneurysm and dissection (TAAD) are associated with connective tissue disorders
like Marfan syndrome and Loeys–Dietz syndrome, caused by mutations in the fibrillin‐1…
like Marfan syndrome and Loeys–Dietz syndrome, caused by mutations in the fibrillin‐1…
[HTML][HTML] Nystagmus in patients with congenital stationary night blindness (CSNB) originates from synchronously firing retinal ganglion cells
BHJ Winkelman, MHC Howlett, MB Hölzel, C Joling… - PLoS …, 2019 - journals.plos.org
Congenital nystagmus, involuntary oscillating small eye movements, is commonly thought to
originate from aberrant interactions between brainstem nuclei and foveal cortical pathways. …
originate from aberrant interactions between brainstem nuclei and foveal cortical pathways. …
Selective impairment of the cerebellar C1 module involved in rat hind limb control reduces step-dependent modulation of cutaneous reflexes
A Pijpers, BHJ Winkelman, R Bronsing… - Journal of …, 2008 - Soc Neuroscience
The cerebellum is divided into multiple parasagittally organized modules, which are thought
to represent functional entities. How individual modules participate in cerebellar control of …
to represent functional entities. How individual modules participate in cerebellar control of …
A common cause for nystagmus in different congenital stationary night blindness mouse models
…, W Kamermans, BHJ Winkelman… - The Journal of …, 2023 - Wiley Online Library
In Nyx nob mice, a model for congenital nystagmus associated with congenital stationary
night blindness (CSNB), synchronous oscillating retinal ganglion cells (RGCs) lead to …
night blindness (CSNB), synchronous oscillating retinal ganglion cells (RGCs) lead to …