Cerebellar output controls generalized spike‐and‐wave discharge occurrence

…, C Strydis, N Davey, BHJ Winkelman… - Annals of …, 2015 - Wiley Online Library
Objective Disrupting thalamocortical activity patterns has proven to be a promising approach
to stop generalized spike‐and‐wave discharges (GSWDs) characteristic of absence …

Purkinje cells in awake behaving animals operate at the upstate membrane potential

M Schonewille, S Khosrovani, BHJ Winkelman… - Nature …, 2006 - nature.com
Over the last decades, cellular bistability or multistable states of the membrane potential
have been demonstrated both in vitro and in vivo for different types of neurons throughout the …

[HTML][HTML] Age-and sex-related differences in contrast sensitivity in C57BL/6 mice

B van Alphen, BHJ Winkelman… - … ophthalmology & visual …, 2009 - iovs.arvojournals.org
purpose. To measure contrast sensitivity in C57BL/6, the most commonly used mouse in
behavioral neuroscience, and to study the effect of sex, age, and miotic drugs on the contrast …

[HTML][HTML] Loss of Gap Junction Delta-2 (GJD2) gene orthologs leads to refractive error in zebrafish

…, RM Lukowicz, S Broekman, BHJ Winkelman… - Communications …, 2021 - nature.com
Myopia is the most common developmental disorder of juvenile eyes, and it has become an
increasing cause of severe visual impairment. The GJD2 locus has been consistently …

[HTML][HTML] Vestibular role of KCNQ4 and KCNQ5 K+ channels revealed by mouse models

G Spitzmaul, L Tolosa, BHJ Winkelman… - Journal of Biological …, 2013 - ASBMB
The function of sensory hair cells of the cochlea and vestibular organs depends on an influx
of K + through apical mechanosensitive ion channels and its subsequent removal over their …

[HTML][HTML] Three-dimensional optokinetic eye movements in the C57BL/6J mouse

B van Alphen, BHJ Winkelman… - … ophthalmology & visual …, 2010 - jov.arvojournals.org
Purpose.: To study three-dimensional optokinetic eye movements of wild-type C57BL/6J
mice, the most commonly used mouse in oculomotor physiology. Optokinetic eye movements …

ACTA2 mutation with childhood cardiovascular, autonomic and brain anomalies and severe outcome

…, Y van Bever, BHJ Winkelman… - American Journal of …, 2013 - Wiley Online Library
Thoracic aortic aneurysm and dissection (TAAD) are associated with connective tissue disorders
like Marfan syndrome and Loeys–Dietz syndrome, caused by mutations in the fibrillin‐1…

[HTML][HTML] Nystagmus in patients with congenital stationary night blindness (CSNB) originates from synchronously firing retinal ganglion cells

BHJ Winkelman, MHC Howlett, MB Hölzel, C Joling… - PLoS …, 2019 - journals.plos.org
Congenital nystagmus, involuntary oscillating small eye movements, is commonly thought to
originate from aberrant interactions between brainstem nuclei and foveal cortical pathways. …

Selective impairment of the cerebellar C1 module involved in rat hind limb control reduces step-dependent modulation of cutaneous reflexes

A Pijpers, BHJ Winkelman, R Bronsing… - Journal of …, 2008 - Soc Neuroscience
The cerebellum is divided into multiple parasagittally organized modules, which are thought
to represent functional entities. How individual modules participate in cerebellar control of …

A common cause for nystagmus in different congenital stationary night blindness mouse models

…, W Kamermans, BHJ Winkelman… - The Journal of …, 2023 - Wiley Online Library
In Nyx nob mice, a model for congenital nystagmus associated with congenital stationary
night blindness (CSNB), synchronous oscillating retinal ganglion cells (RGCs) lead to …