The spliceosome is a staggeringly complex machine, comprising, in humans, 5 snRNAs and
>150 proteins. We scaled haploid CRISPR-Cas9 base editing to target the entire human …

We determined that over 40 spliceosomal proteins are conserved between many fungal
species and humans but were lost during the evolution of S. cerevisiae, an intron-poor yeast …

Little is understood about how the two major types of heterochromatin domains (HP1 and
Polycomb) are kept separate. In the yeast Cryptococcus neoformans, the Polycomb-like protein …

Tools to understand how the spliceosome functions in vivo have lagged behind advances in
the structural biology of the spliceosome. Here, methods are described to globally profile …

Epigenetic evolution occurs over million-year timescales in Cryptococcus neoformans and is
mediated by DNMT5, the first maintenance type cytosine methyltransferase identified in the …

The human pathogenic yeast Cryptococcus neoformans silences transposable elements
using endo-siRNAs and an Argonaute, Ago1. Endo-siRNAs production requires the RNA-…

Qsp1 is a secreted quorum sensing peptide required for virulence of the fungal meningitis
pathogen Cryptococcus neoformans. Qsp1 functions to control cell wall integrity in …

Epigenetic evolution occurs over million-year timescales in Cryptococcus neoformans and is
mediated by DNMT5, the first maintenance-type cytosine methyltransferase identified in the …

The GSA and the fungal genetics community have a long relationship given their joint
sponsorship of the Asilomar Fungal Genetics meeting, and GENETICS has a long and rich history …

Road transport is the primary means to transit goods and people from one place to another
at the global level. But the slowdown of flow of vehicles, due to internal and external factors, …