Munc13 catalyzes the transit of syntaxin from a closed complex with Munc18 into the ternary
SNARE complex. Here we report a new function of Munc13, independent of Munc18: it …

Dendritic spines are the major transmitter reception compartments of glutamatergic synapses
in most principal neurons of the mammalian brain and play a key role in the function of …

Erythropoietin (EPO) exerts potent neuroprotective, neuroregenerative and procognitive
functions. However, unequivocal demonstration of erythropoietin receptor (EPOR) expression in …

Although similar in molecular composition, synapses can exhibit strikingly distinct functional
transmitter release and plasticity characteristics. To determine whether ultrastructural …

The establishment of axon-dendrite polarity is fundamental for radial migration of neurons
during cortex development of mammals. We demonstrate that the E3 ubiquitin ligases WW-…

Kaufman oculocerebrofacial syndrome (KOS) is a severe autosomal recessive disorder
characterized by intellectual disability, developmental delays, microcephaly, and characteristic …

Brain-derived neurotrophic factor (BDNF) is widely reported to enhance synaptic vesicle (SV)
exocytosis and neurotransmitter release. But it is still unclear whether BDNF enhances SV …

Cas9 targets genomic loci with high specificity. For knockin with double-strand break repair,
however, Cas9 often leads to unintended on-target knockout rather than intended edits. This …

Nedd4-2 is an E3 ubiquitin ligase in which missense mutation is related to familial epilepsy,
indicating its critical role in regulating neuronal network activity. However, Nedd4-2 …

The kinase mTOR is a signaling hub for pathways that regulate cellular growth. In neurons,
the subcellular localization of mTOR takes on increased significance. Here, we review …