The signal-response characteristics of a living cell are determined by complex networks of
interacting genes, proteins, and metabolites. Understanding how cells respond to specific …

The physiological responses of cells to external and internal stimuli are governed by genes
and proteins interacting in complex networks whose dynamical properties are impossible to …

… the editors of this issue, Kim Nasmyth and Bela Novak. Murdoch took a keen interest in the
cell cycle field until the very end, and his passing marks the end of an exciting and heroic era. …

Following DNA damage caused by exogenous sources, such as ionizing radiation, the
tumour suppressor p53 mediates cell cycle arrest via expression of the CDK inhibitor, p21. …

… An inhibitor-amplified negative-feedback loop (in which X is Cdc10, Y is Cig2 and Z is Rum1)
has been used by Novak and Tyson 49 to model endoreplication (periodic DNA synthesis …

A central event in the eukaryotic cell cycle is the decision to commence DNA replication (S
phase). Strict controls normally operate to prevent repeated rounds of DNA replication without …

Inhibition of protein synthesis by cycloheximide blocks subsequent division of a mammalian
cell, but only if the cell is exposed to the drug before the “restriction point” (ie within the first …

We propose a protein interaction network for the regulation of DNA synthesis and mitosis
that emphasizes the universality of the regulatory system among eukaryotic cells. The …

p53 is activated in response to events compromising the genetic integrity of a cell. Recent
data show that p53 activity does not increase steadily with genetic damage but rather …

The molecular machinery of cell cycle control is known in more detail for budding yeast,
Saccharomyces cerevisiae, than for any other eukaryotic organism. In recent years, many …