Breast cancer risk is influenced by rare coding variants in susceptibility genes, such as
BRCA1, and many common, mostly non-coding variants. However, much of the genetic …

Background: Common cancers develop through a multistep process often including inherited
susceptibility. Collaboration among multiple institutions, and funding from multiple sources, …

INTRODUCTION Variation in pigmentation among human populations may reflect local
adaptation to regional light environments, because dark skin is more photoprotective, whereas …

INTRODUCTION The 1986 Chernobyl (Chornobyl in Ukrainian) nuclear power plant accident
exposed millions of individuals in the surrounding region to radioactive contaminants, …

Importance Osteosarcoma, the most common malignant bone tumor in children and adolescents,
occurs in a high number of cancer predisposition syndromes that are defined by highly …

Most genetic susceptibility to cutaneous melanoma remains to be discovered. Meta-analysis
genome-wide association study (GWAS) of 36,760 cases of melanoma (67% newly …

High-throughput RNA sequencing (RNA-seq) greatly expands the potential for genomics
discoveries, but the wide variety of platforms, protocols and performance capabilitites has …

PURPOSE Rhabdomyosarcoma is the most common soft tissue sarcoma of childhood.
Despite aggressive therapy, the 5-year survival rate for patients with metastatic or recurrent …

The breast cancer risk variants identified in genome-wide association studies explain only a
small fraction of the familial relative risk, and the genes responsible for these associations …

Background Single nucleotide polymorphisms (SNPs) have emerged as the genetic marker
of choice for mapping disease loci and candidate gene association studies, because of their …