A molecular switch and proton wire synchronize the active sites in thiamine enzymes
Thiamine diphosphate (ThDP) is used as a cofactor in many key metabolic enzymes. We
present evidence that the ThDPs in the two active sites of the E1 (EC 1.2.4.1) component of the …
present evidence that the ThDPs in the two active sites of the E1 (EC 1.2.4.1) component of the …
Hfq and its constellation of RNA
J Vogel, BF Luisi - Nature Reviews Microbiology, 2011 - nature.com
Hfq is an RNA-binding protein that is common to diverse bacterial lineages and has key roles
in the control of gene expression. By facilitating the pairing of small RNAs with their target …
in the control of gene expression. By facilitating the pairing of small RNAs with their target …
Multidrug efflux pumps: structure, function and regulation
…, KM Pos, LJV Piddock, BF Luisi - Nature Reviews …, 2018 - nature.com
Infections arising from multidrug-resistant pathogenic bacteria are spreading rapidly throughout
the world and threaten to become untreatable. The origins of resistance are numerous …
the world and threaten to become untreatable. The origins of resistance are numerous …
Structure of the AcrAB–TolC multidrug efflux pump
The capacity of numerous bacterial species to tolerate antibiotics and other toxic compounds
arises in part from the activity of energy-dependent transporters. In Gram-negative bacteria, …
arises in part from the activity of energy-dependent transporters. In Gram-negative bacteria, …
The function and structure of the metal coordination sites within the glucocorticoid receptor DNA binding domain
LP Freedman, BF Luisi, ZR Korszun, R Basavappa… - Nature, 1988 - nature.com
The glucocorticoid receptor enhances or represses transcription by binding to specific DNA
sequences termed glucocorticoid response elements, or GREs 1–5 . Studies of cloned …
sequences termed glucocorticoid response elements, or GREs 1–5 . Studies of cloned …
Structure of Escherichia coli RNase E catalytic domain and implications for RNA turnover
…, JA Stead, KJ McDowall, WG Scott, BF Luisi - Nature, 2005 - nature.com
The coordinated regulation of gene expression is required for homeostasis, growth and
development in all organisms. Such coordination may be partly achieved at the level of …
development in all organisms. Such coordination may be partly achieved at the level of …
[PDF][PDF] A duplicated fold is the structural basis for polynucleotide phosphorylase catalytic activity, processivity, and regulation
MF Symmons, GH Jones, BF Luisi - Structure, 2000 - cell.com
Background: Polynucleotide phosphorylase (PNPase) is a polyribonucleotide nucleotidyl
transferase (EC2.7.7.8) that degrades mRNA in prokaryotes. Streptomyces antibioticus …
transferase (EC2.7.7.8) that degrades mRNA in prokaryotes. Streptomyces antibioticus …
An allosteric transport mechanism for the AcrAB-TolC multidrug efflux pump
10.7554/eLife.24905.001 Bacterial efflux pumps confer multidrug resistance by transporting
diverse antibiotics from the cell. In Gram-negative bacteria, some of these pumps form multi-…
diverse antibiotics from the cell. In Gram-negative bacteria, some of these pumps form multi-…
[PDF][PDF] Structural basis for the recognition of histone H4 by the histone-chaperone RbAp46
…, SH McLaughlin, TR Ben-Shahar, A Verreault, BF Luisi… - Structure, 2008 - cell.com
RbAp46 and RbAp48 (pRB-associated proteins p46 and p48, also known as RBBP7 and
RBBP4, respectively) are highly homologous histone chaperones that play key roles in …
RBBP4, respectively) are highly homologous histone chaperones that play key roles in …
[PDF][PDF] In vivo cleavage map illuminates the central role of RNase E in coding and non-coding RNA pathways
…, K Papenfort, R Reinhardt, HJ Wieden, BF Luisi… - Molecular cell, 2017 - cell.com
Understanding RNA processing and turnover requires knowledge of cleavages by major
endoribonucleases within a living cell. We have employed TIER-seq (transiently inactivating an …
endoribonucleases within a living cell. We have employed TIER-seq (transiently inactivating an …