Cancer cells differ in size from those of their host tissue and are known to change in size
during the processes of cell death. A noninvasive method for monitoring cell size would be …

Introduction To combine numerical simulations, in vitro and in vivo experiments to evaluate
the feasibility of measuring diffusion exchange across the cell membrane with diffusion …

INTRODUCTION Maximal surgical resection for the malignant brain tumour Glioblastoma (GBM)
inevitably leaves residual disease that disseminates predominantly along white matter …

There has been slow progress in the development of new therapeutic strategies for treating
brain tumours, partly because assessment of treatment response is difficult and largely …

Artificial neural networks are being widely implemented for a range of different biomedical
imaging applications.Convolutional neural networks are by far the most popular type of deep …

… I, Benjamin Oliver Richard Hipwell, confirm that the work presented in this thesis is my
own. Where information has been derived from other sources, I confirm that this has been …

PURPOSE: The purpose of this study was to develop a realistic in-silico model of the diffusion
MRI signal in tumour tissue, using three-dimensional, high-resolution imaging data from …

The permeability of cell membranes varies significantly across both healthy and diseased
tissue, and changes in cell membrane permeability can occur during treatment response in …

… Roberts1, Giulia Agliardi1, Ben Hipwell1, Angela D’Esposito1, Andrada Ianus2, James O.
BreenNorris1, Valerie Taylor1, Mark F. Lythgoe1,Bernard Siow1, Eleftheria Panagiotaki2 …

Compartmental models are increasingly being used to quantify diffusion MRI signals from
tumours. We have developed a complex, multiscale mathematical modelling platform for …