Preoperative radiotherapy (RT) is a mainstay in the management of rectal cancer, a tumor
characterized by desmoplastic stroma containing cancer-associated fibroblasts (CAF). …

A generic site‐specific conjugation method that generates a homogeneous product is of
utmost importance in tracer development for molecular imaging and therapy. We explored the …

This study reports on the design of mRNA and adjuvant-loaded lipid nanoparticles for
therapeutic cancer vaccination. The use of nucleoside-modified mRNA has previously been …

Background: Differences in brain energy metabolism have been found between migraine
patients and controls in previous phosphorus magnetic resonance spectroscopy ( 31 P-MRS) …

Aims Positron emission tomography–computed tomography (PET-CT) is a highly sensitive
clinical molecular imaging modality to study atherosclerotic plaque biology. Therefore, we …

Intravenous administration of siRNA nanocarriers may provide unique therapeutic opportunities
for tissue-specific gene silencing. Although often engineered to overcome the numerous …

Background Functional disturbances of the endoplasmic reticulum (ER) lead to activation of
the unfolded protein response (UPR), which is involved in the consecutive steps of …

Intra-abdominal dissemination of peritoneal nodules, a condition known as peritoneal
carcinomatosis (PC), is typically diagnosed in ovarian cancer patients at the advanced stages. The …

Radiotherapeutic treatment consists of targeted application of radiation beams to a tumor but
exposure of surrounding healthy tissue is inevitable. In the brain, ionizing radiation induces …

Cytoreductive surgery combined with intraperitoneal chemotherapy (IPC) is currently the
standard treatment for selected patients with peritoneal carcinomatosis of colorectal cancer. …