The development of next-generation sequencing (NGS) technologies for HLA and KIR
genotyping is rapidly advancing knowledge of genetic variation of these highly polymorphic loci. …

We have determined how most of the transcriptional regulators encoded in the eukaryote
Saccharomyces cerevisiaeassociate with genes across the genome in living cells. Just as …

DNA-binding transcriptional regulators interpret the genome's regulatory code by binding to
specific sequences to induce or repress gene expression 1 . Comparative genomics has …

We describe an algorithm for discovering regulatory networks of gene modules, GRAM (Genetic
Regulatory Modules), that combines information from genome-wide location and …

Regulators were tagged by inserting multiple copies of the Myc epitope coding sequence
into the normal chomosomal loci of these genes. The plasmid pWZV88 (1) was used as a …

The transcriptional regulatory networks that specify and maintain human tissue diversity are
largely uncharted. To gain insight into this circuitry, we used chromatin immunoprecipitation …

Background The regulatory map of a genome consists of the binding sites for proteins that
determine the transcription of nearby genes. An initial regulatory map for S. cerevisiae was …

Motivation: Genome-wide chromatin-immunoprecipitation (ChIP-chip) detects binding of
transcriptional regulators to DNA in vivo at low resolution. Motif discovery algorithms can be …

… Benjamin Franklin, however, raised the ante on both of them with a version that is normally
attributed to Blackstone: "That it is better 100 guilty Persons should escape than that one …

We discuss a method of combining genome-wide transcription factor binding data, gene
expression data, and genome sequence data for the purpose of motif discovery in S. cerevisiae. …