Fragile X syndrome (FXS) is the most common form of heritable mental retardation and the
leading identified cause of autism. FXS is caused by transcriptional silencing of the FMR1 …

Tuberous sclerosis complex and fragile X syndrome are genetic diseases characterized by
intellectual disability and autism. Because both syndromes are caused by mutations in genes …

Sensorineural hearing loss induced by noise or ototoxic drug exposure reduces the neural
activity transmitted from the cochlea to the central auditory system. Despite a reduced …

Loss of the translational repressor FMRP causes Fragile X syndrome. In healthy neurons,
FMRP modulates the local translation of numerous synaptic proteins. Synthesis of these …

There are three times as many outer hair cells (OHC) as inner hair cells (IHC), yet IHC
transmit virtually all acoustic information to the brain as they synapse with 90–95% of type I …

Fragile X Syndrome (FXS) is a leading inherited cause of autism and intellectual disability,
resulting from mutation in the FMR1 gene and subsequent loss of its protein product FMRP. …

Inhibitors of phosphodiesterase-4 (PDE4) have beneficial effects on memory in preclinical
and clinical studies. Development of these drugs has stalled due to dose-limiting side effects …

Synaptic protein synthesis is essential for modification of the brain by experience and is
aberrant in several genetically defined disorders, notably fragile X (FX), a heritable cause of …

Autism spectrum disorders (ASD) are strongly associated with auditory hypersensitivity or
hyperacusis (difficulty tolerating sounds). Fragile X syndrome (FXS), the most common …

Listening in noisy or complex sound environments is difficult for individuals with normal
hearing and can be a debilitating impairment for those with hearing loss. Extracting meaningful …