User profiles for Benjamin D. Cosgrove

Benjamin D. Cosgrove

Assistant Professor, Cornell University
Verified email at cornell.edu
Cited by 2896

Rejuvenation of the muscle stem cell population restores strength to injured aged muscles

BD Cosgrove, PM Gilbert, E Porpiglia, F Mourkioti… - Nature medicine, 2014 - nature.com
The elderly often suffer from progressive muscle weakness and regenerative failure. We
demonstrate that muscle regeneration is impaired with aging owing in part to a cell-autonomous …

The central role of muscle stem cells in regenerative failure with aging

HM Blau, BD Cosgrove, ATV Ho - Nature medicine, 2015 - nature.com
Skeletal muscle mass, function, and repair capacity all progressively decline with aging,
restricting mobility, voluntary function, and quality of life. Skeletal muscle repair is facilitated by a …

[PDF][PDF] Single-cell analysis of the muscle stem cell hierarchy identifies heterotypic communication signals involved in skeletal muscle regeneration

…, I De Vlaminck, O Elemento, BD Cosgrove - Cell reports, 2020 - cell.com
Muscle regeneration relies on the regulation of muscle stem cells (MuSCs) through paracrine
signaling interactions. We analyzed muscle regeneration in mice using single-cell RNA …

[HTML][HTML] Large-scale integration of single-cell transcriptomic data captures transitional progenitor states in mouse skeletal muscle regeneration

…, MFZ Wang, I De Vlaminck, BD Cosgrove - Communications …, 2021 - nature.com
Skeletal muscle repair is driven by the coordinated self-renewal and fusion of myogenic
stem and progenitor cells. Single-cell gene expression analyses of myogenesis have been …

Combinatorial treatment rescues tumour-microenvironment-mediated attenuation of MALT1 inhibitors in B-cell lymphomas

…, C Steidl, DW Scott, L Fontan, H Ueno, BD Cosgrove… - Nature Materials, 2023 - nature.com
Activated B-cell-like diffuse large B-cell lymphomas (ABC-DLBCLs) are characterized by
constitutive activation of nuclear factor κB driven by the B-cell receptor (BCR) and Toll-like …

[HTML][HTML] Spatial mapping of the total transcriptome by in situ polyadenylation

…, JSL Parker, P Sethupathy, BD Cosgrove… - Nature …, 2023 - nature.com
Spatial transcriptomics reveals the spatial context of gene expression, but current methods
are limited to assaying polyadenylated (A-tailed) RNA transcripts. Here we demonstrate that …

A home away from home: challenges and opportunities in engineering in vitro muscle satellite cell niches

BD Cosgrove, A Sacco, PM Gilbert, HM Blau - Differentiation, 2009 - Elsevier
Satellite cells are skeletal muscle stem cells with a principal role in postnatal skeletal muscle
regeneration. Satellite cells, like many tissue-specific adult stem cells, reside in a quiescent …

[HTML][HTML] A reference single-cell transcriptomic atlas of human skeletal muscle tissue reveals bifurcated muscle stem cell populations

AJ De Micheli, JA Spector, O Elemento, BD Cosgrove - Skeletal muscle, 2020 - Springer
Single-cell RNA-sequencing (scRNA-seq) facilitates the unbiased reconstruction of multicellular
tissue systems in health and disease. Here, we present a curated scRNA-seq dataset of …

Synergistic drug–cytokine induction of hepatocellular death as an in vitro approach for the study of inflammation-associated idiosyncratic drug hepatotoxicity

BD Cosgrove, BM King, MA Hasan… - Toxicology and applied …, 2009 - Elsevier
Idiosyncratic drug hepatotoxicity represents a major problem in drug development due to
inadequacy of current preclinical screening assays, but recently established rodent models …

High-resolution myogenic lineage mapping by single-cell mass cytometry

E Porpiglia, N Samusik, ATV Ho, BD Cosgrove… - Nature cell …, 2017 - nature.com
Muscle regeneration is a dynamic process during which cell state and identity change over
time. A major roadblock has been a lack of tools to resolve a myogenic progression in vivo. …