Phosphatase and tensin homolog on chromosome ten (PTEN) is a tumor suppressor and
an antagonist of the phosphoinositide-3 kinase (PI3K) pathway. We identified a 576–amino …

Cancer is driven by incremental changes that accumulate, eventually leading to oncogenic
transformation. Although genetic alterations dominate the way cancer biologists think about …

Mutations in PIK3CA, which encodes the p110α subunit of the insulin-activated
phosphatidylinositol-3 kinase (PI3K), and loss of function mutations in PTEN, which encodes a …

Obesity is a risk factor for cancer development and is associated with poor prognosis in
multiple tumor types. The positive energy balance linked with obesity induces a variety of …

Phosphoinositide 3-kinase (PI3K) activity is stimulated by diverse oncogenes and growth
factor receptors, and elevated PI3K signaling is considered a hallmark of cancer. Many PI3K …

Protein phosphorylation is one of the most widespread post-translational modifications in
biology 1 , 2 . With advances in mass-spectrometry-based phosphoproteomics, 90,000 sites of …

Precision medicine is an approach that takes into account the influence of individuals' genes,
environment, and lifestyle exposures to tailor interventions. Here, we describe the …

Phosphatase and tensin homolog deleted on chromosome ten (PTEN) is a phosphatase that
is frequently altered in cancer. PTEN has phosphatase-dependent and -independent roles, …

The Central Role of PI3K in Cell Signaling Phosphatidylinositol 3-kinase (PI3K) is involved
in multiple cell processes, including insulin signaling, cell growth, immunity, and brain …

Tetraspanin protein CD151 is abundant on endothelial cells. To determine whether CD151
affects angiogenesis, Cd151-null mice were prepared. Cd151-null mice showed no vascular …