Differential phosphatidylinositol-3-kinase-Akt-mTOR activation by Semliki Forest and chikungunya viruses is dependent on nsP3 and connected to replication complex …
…, R Biasiotto, K Eng, M Neuvonen, B Götte… - Journal of …, 2015 - Am Soc Microbiol
Many viruses affect or exploit the phosphatidylinositol-3-kinase (PI3K)-Akt-mammalian target
of rapamycin (mTOR) pathway, a crucial prosurvival signaling cascade. We report that this …
of rapamycin (mTOR) pathway, a crucial prosurvival signaling cascade. We report that this …
[HTML][HTML] The enigmatic alphavirus non-structural protein 3 (nsP3) revealing its secrets at last
B Götte, L Liu, GM McInerney - Viruses, 2018 - mdpi.com
Alphaviruses encode 4 non-structural proteins (nsPs), most of which have well-understood
functions in capping and membrane association (nsP1), polyprotein processing and RNA …
functions in capping and membrane association (nsP1), polyprotein processing and RNA …
[PDF][PDF] A rapid RIG-I signaling relay mediates efficient antiviral response
DT Thoresen, D Galls, B Götte, W Wang, AM Pyle - Molecular cell, 2023 - cell.com
RIG-I is essential for host defense against viral pathogens, as it triggers the release of type I
interferons upon encounter with viral RNA molecules. In this study, we show that RIG-I is …
interferons upon encounter with viral RNA molecules. In this study, we show that RIG-I is …
Combined structural, biochemical and cellular evidence demonstrates that both FGDF motifs in alphavirus nsP3 are required for efficient replication
…, MD Panas, B Thaa, N Dickson, B Götte… - Open …, 2016 - royalsocietypublishing.org
Recent findings have highlighted the role of the Old World alphavirus non-structural protein
3 (nsP3) as a host defence modulator that functions by disrupting stress granules, …
3 (nsP3) as a host defence modulator that functions by disrupting stress granules, …
[HTML][HTML] Separate domains of G3BP promote efficient clustering of alphavirus replication complexes and recruitment of the translation initiation machinery
B Götte, MD Panas, K Hellström, L Liu… - PLoS …, 2019 - journals.plos.org
G3BP-1 and -2 (hereafter referred to as G3BP) are multifunctional RNA-binding proteins
involved in stress granule (SG) assembly. Viruses from diverse families target G3BP for …
involved in stress granule (SG) assembly. Viruses from diverse families target G3BP for …
[HTML][HTML] The E3 ligase Riplet promotes RIG-I signaling independent of RIG-I oligomerization
W Wang, B Götte, R Guo, AM Pyle - Nature Communications, 2023 - nature.com
RIG-I is an essential innate immune receptor that responds to infection by RNA viruses. The
RIG-I signaling cascade is mediated by a series of post-translational modifications, the most …
RIG-I signaling cascade is mediated by a series of post-translational modifications, the most …
Sensitivity of alphaviruses to G3BP deletion correlates with efficiency of replicase polyprotein processing
B Götte, A Utt, R Fragkoudis, A Merits… - Journal of …, 2020 - Am Soc Microbiol
We present a comprehensive overview of the dependency of several Old World alphaviruses
for the host protein G3BP. Based on their replication ability in G3BP-deleted cells, Old …
for the host protein G3BP. Based on their replication ability in G3BP-deleted cells, Old …
[HTML][HTML] Arabidopsis thaliana G3BP Ortholog Rescues Mammalian Stress Granule Phenotype across Kingdoms
H Reuper, B Götte, L Williams, TJC Tan… - International Journal of …, 2021 - mdpi.com
Stress granules (SGs) are dynamic RNA–protein complexes localized in the cytoplasm that
rapidly form under stress conditions and disperse when normal conditions are restored. The …
rapidly form under stress conditions and disperse when normal conditions are restored. The …
RNA processing bodies are disassembled during Old World alphavirus infection
L Liu, E Weiss, MD Panas, B Götte… - Journal of General …, 2019 - microbiologyresearch.org
RNA processing bodies (P-bodies) are non-membranous cytoplasmic aggregates of mRNA
and proteins involved in mRNA decay and translation repression. P-bodies actively respond …
and proteins involved in mRNA decay and translation repression. P-bodies actively respond …
Functional homo-and heterodimeric actin capping proteins from the malaria parasite
Actin capping proteins belong to the core set of proteins minimally required for actin-based
motility and are present in virtually all eukaryotic cells. They bind to the fast-growing barbed …
motility and are present in virtually all eukaryotic cells. They bind to the fast-growing barbed …