[PDF][PDF] Transferrin receptor is a specific ferroptosis marker

H Feng, K Schorpp, J Jin, CE Yozwiak, BG Hoffstrom… - Cell reports, 2020 - cell.com
Ferroptosis is a type of regulated cell death driven by the iron-dependent accumulation of
oxidized polyunsaturated fatty acid-containing phospholipids. There is no reliable way to …

FDA-approved selective estrogen receptor modulators inhibit Ebola virus infection

…, A Stossel, C Lear, BG Hoffstrom… - Science translational …, 2013 - science.org
Ebola viruses remain a substantial threat to both civilian and military populations as
bioweapons, during sporadic outbreaks, and from the possibility of accidental importation from …

Inhibitors of protein disulfide isomerase suppress apoptosis induced by misfolded proteins

BG Hoffstrom, A Kaplan, R Letso, RS Schmid… - Nature chemical …, 2010 - nature.com
A hallmark of many neurodegenerative diseases is accumulation of misfolded proteins
within neurons, leading to cellular dysfunction and cell death. Although several mechanisms …

Inhibition of pp125FAK in cultured fibroblasts results in apoptosis.

…, MT Compton, ML Matter, BG Hoffstrom… - The Journal of cell …, 1996 - rupress.org
The tyrosine kinase called pp125FAK is believed to play an important role in integrin-mediated
signal transduction. pp125FAK is associated both functionally and spatially with integrins, …

A screen of approved drugs and molecular probes identifies therapeutics with anti–Ebola virus activity

…, LE DeWald, CJ Shoemaker, BG Hoffstrom… - Science translational …, 2015 - science.org
Currently, no approved therapeutics exist to treat or prevent infections induced by Ebola
viruses, and recent events have demonstrated an urgent need for rapid discovery of new …

[HTML][HTML] Structural basis for broad coronavirus neutralization

…, J Quispe, BG Hoffstrom… - Nature structural & …, 2021 - nature.com
Three highly pathogenic β-coronaviruses have crossed the animal-to-human species
barrier in the past two decades: SARS-CoV, MERS-CoV and SARS-CoV-2. To evaluate the …

Analysis of ROR1 protein expression in human cancer and normal tissues

…, J Randolph-Habecker, BG Hoffstrom… - Clinical Cancer …, 2017 - AACR
Purpose: This study examines cell surface ROR1 expression in human tumors and normal
tissues. ROR1 is considered a promising target for cancer therapy due to putative tumor-…

Mesendoderm extension and mantle closure in Xenopus laevis gastrulation: combined roles for integrin α5β1, fibronectin, and tissue geometry

LA Davidson, BG Hoffstrom, R Keller… - Developmental …, 2002 - Elsevier
We describe mesendoderm morphogenesis during gastrulation in the frog Xenopus laevis
and investigate the mechanics of these movements with tissue explants. When a dorsal …

[HTML][HTML] Integrin α5β1 supports the migration of Xenopus cranial neural crest on fibronectin

D Alfandari, H Cousin, A Gaultier, BG Hoffstrom… - Developmental …, 2003 - Elsevier
During early embryonic development, cranial neural crest cells emerge from the developing
mid- and hindbrain. While numerous studies have focused on integrin involvement in trunk …

[HTML][HTML] A kinase-deficient NTRK2 splice variant predominates in glioma and amplifies several oncogenic signaling pathways

…, P Hoellerbauer, T Bonifert, BG Hoffstrom… - Nature …, 2020 - nature.com
Independent scientific achievements have led to the discovery of aberrant splicing patterns
in oncogenesis, while more recent advances have uncovered novel gene fusions involving …