The brain’s ability to associate different stimuli is vital for long-term memory, but how neural
ensembles encode associative memories is unknown. Here we studied how cell ensembles …

Two-photon calcium imaging of neuronal populations enables optical recording of spiking
activity in living animals, but standard laser scanners are too slow to accurately determine …

To study brain function, preclinical research heavily relies on animal monitoring and the
subsequent analyses of behavior. Commercial platforms have enabled semi high-throughput …

Genetically encoded voltage indicators (GEVIs) are a promising technology for fluorescence
readout of millisecond-scale neuronal dynamics. Previous GEVIs had insufficient signaling …

Artificial neural networks suffer from catastrophic forgetting when they are sequentially trained
on multiple tasks. To overcome this problem, we present a novel approach based on task-…

Loss of dopamine in Parkinson's disease is hypothesized to impede movement by inducing
hypo- and hyperactivity in striatal spiny projection neurons (SPNs) of the direct (dSPNs) and …

Functional two-photon Ca^2+-imaging is a versatile tool to study the dynamics of neuronal
populations in brain slices and living animals. However, population imaging is typically …

Optogenetics with microbial opsin genes has enabled high-speed control of genetically
specified cell populations in intact tissue. However, it remains a challenge to independently …

Pain is an unpleasant experience. How the brain’s affective neural circuits attribute this
aversive quality to nociceptive information remains unknown. By means of time-lapse in vivo …

Memories about sensory experiences are tightly linked to the context in which they were
formed. Memory contextualization is fundamental for the selection of appropriate behavioral …