User profiles for Benjamin J. Doranz
 | Benjamin DoranzIntegral Molecular Verified email at integralmolecular.com Cited by 20003 |
Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene
M Samson, F Libert, BJ Doranz, J Rucker, C Liesnard… - Nature, 1996 - nature.com
HIV-1 and related viruses require co-receptors, in addition to CD4, to infect target cells. The
chemokine receptor CCR-5 (ref. 1) was recently demonstrated to be a co-receptor for …
chemokine receptor CCR-5 (ref. 1) was recently demonstrated to be a co-receptor for …
[HTML][HTML] A dual-tropic primary HIV-1 isolate that uses fusin and the β-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors
BJ Doranz, J Rucker, Y Yi, RJ Smyth, M Samson… - Cell, 1996 - cell.com
Here, we show that the β-chemokine receptor CKR-5 serves as a cofactor for M-tropic HIV
viruses. Expression of CKR-5 with CD4 enables nonpermissive cells to form syncytia with cells …
viruses. Expression of CKR-5 with CD4 enables nonpermissive cells to form syncytia with cells …
[PDF][PDF] Neutralizing and protective human monoclonal antibodies recognizing the N-terminal domain of the SARS-CoV-2 spike protein
…, EC Chen, ME Fouch, E Davidson, BJ Doranz… - Cell, 2021 - cell.com
Most human monoclonal antibodies (mAbs) neutralizing SARS-CoV-2 recognize the spike (S)
protein receptor-binding domain and block virus interactions with the cellular receptor …
protein receptor-binding domain and block virus interactions with the cellular receptor …
Comprehensive analysis of dengue virus-specific responses supports an HLA-linked protective role for CD8+ T cells
…, AM de Silva, KA Mattia, BJ Doranz… - Proceedings of the …, 2013 - National Acad Sciences
The role of CD8 + T cells in dengue virus infection and subsequent disease manifestations
is not fully understood. According to the original antigenic sin theory, skewing of T-cell …
is not fully understood. According to the original antigenic sin theory, skewing of T-cell …
A seven-transmembrane domain receptor involved in fusion and entry of T-cell-tropic human immunodeficiency virus type 1 strains
JF Berson, D Long, BJ Doranz, J Rucker… - Journal of …, 1996 - Am Soc Microbiol
Entry of human immunodeficiency virus type 1 (HIV-1) into cells requires binding to CD4 and
fusion with a cellular membrane. Fusion does not occur in most nonhuman cells even when …
fusion with a cellular membrane. Fusion does not occur in most nonhuman cells even when …
[HTML][HTML] Epitope mapping of CCR5 reveals multiple conformational states and distinct but overlapping structures involved in chemokine and coreceptor function
…, M Sharron, C Blanpain, BJ Doranz, J Vakili… - Journal of Biological …, 1999 - ASBMB
The chemokine receptor CCR5 is the major coreceptor for R5 human immunodeficiency
virus type-1 strains. We mapped the epitope specificities of 18 CCR5 monoclonal antibodies (…
virus type-1 strains. We mapped the epitope specificities of 18 CCR5 monoclonal antibodies (…
Neutralizing human antibodies prevent Zika virus replication and fetal disease in mice
Zika virus (ZIKV) is an emerging mosquito-transmitted flavivirus that can cause severe disease,
including congenital birth defects during pregnancy 1. To develop candidate therapeutic …
including congenital birth defects during pregnancy 1. To develop candidate therapeutic …
CCR5 binds multiple CC-chemokines: MCP-3 acts as a natural antagonist
CCR5 was first characterized as a receptor for MIP-1, MIP-1β, and RANTES, and was
rapidly shown to be the main coreceptor for M-tropic human immunodeficiency virus (HIV)-1 …
rapidly shown to be the main coreceptor for M-tropic human immunodeficiency virus (HIV)-1 …
Mxra8 is a receptor for multiple arthritogenic alphaviruses
…, RH Fong, H Lin, S Poddar, JE Crowe Jr, BJ Doranz… - Nature, 2018 - nature.com
Arthritogenic alphaviruses comprise a group of enveloped RNA viruses that are transmitted
to humans by mosquitoes and cause debilitating acute and chronic musculoskeletal disease …
to humans by mosquitoes and cause debilitating acute and chronic musculoskeletal disease …
A small-molecule inhibitor directed against the chemokine receptor CXCR4 prevents its use as an HIV-1 coreceptor
BJ Doranz, K Grovit-Ferbas, MP Sharron… - The Journal of …, 1997 - rupress.org
The chemokine receptor CXCR4 is the major coreceptor used for cellular entry by T cell–
tropic human immunodeficiency virus (HIV)-1 strains, whereas CCR5 is used by macrophage (…
tropic human immunodeficiency virus (HIV)-1 strains, whereas CCR5 is used by macrophage (…