Analyses of data from genome-wide association studies on unrelated individuals have shown
that, for human traits and diseases, approximately one-third to two-thirds of heritability is …

… At Vanderbilt, this work was supported by grants from the American Heart Association to Dr
Shoemaker ( 11CRP7420009 ), Dr Darbar ( EIA 0940116 N ), and grants from the National …

Background: Ablation is a widely used therapy for atrial fibrillation (AF); however, arrhythmia
recurrence and repeat procedures are common. Studies examining surrogate markers of …

The Trans-Omics for Precision Medicine (TOPMed) programme seeks to elucidate the genetic
architecture and biology of heart, lung, blood and sleep disorders, with the ultimate goal of …

Age is the dominant risk factor for most chronic human diseases, but the mechanisms
through which ageing confers this risk are largely unknown 1 . The age-related acquisition of …

Susceptibility to atrial fibrillation (AF) is determined by well-recognized risk factors such as
diabetes mellitus or hypertension, emerging risk factors such as sleep apnea or inflammation, …

Atrial fibrillation affects more than 33 million people worldwide and increases the risk of
stroke, heart failure, and death 1 , 2 . Fourteen genetic loci have been associated with atrial …

Importance Early-onset atrial fibrillation (AF) can be the initial manifestation of a more serious
underlying inherited cardiomyopathy or arrhythmia syndrome. Objective To examine the …

Mutations in a diverse set of driver genes increase the fitness of haematopoietic stem cells (HSCs),
leading to clonal haematopoiesis 1 . These lesions are precursors for blood cancers …

Importance Atrial fibrillation (AF) is the most common arrhythmia affecting 1% of the population.
Young individuals with AF have a strong genetic association with the disease, but the …