Factor-induced reprogramming of somatic cells into induced pluripotent stem cells (iPSCs)
is inefficient, complicating mechanistic studies. Here, we examined defined intermediate cell …

Effective therapies to treat coronavirus disease 2019 (COVID-19) are urgently needed. While
many investigational, approved, and repurposed drugs have been suggested as potential …

The tumor microenvironment (TME) influences cancer progression and therapy response.
Therefore, understanding what regulates the TME immune compartment is vital. Here we …

Machine code disassembly routines form a fundamental component of software systems that
statically analyze or modify executable programs, eg, reverse engineering systems, static …

Soil organisms, including earthworms, are a key component of terrestrial ecosystems. However,
little is known about their diversity, their distribution, and the threats affecting them. We …

T lymphopoiesis requires settling of the thymus by bone marrow–derived precursors throughout
adult life. Progenitor entry into the thymus is selective, but the molecular basis of this …

Intestinal mucus forms the first line of defense against bacterial invasion while providing
nutrition to support microbial symbiosis. How the host controls mucus barrier integrity and …

The COVID-19 pandemic progresses unabated in many regions of the world. An effective
antiviral against SARS-CoV-2 that could be administered orally for use following high-risk …

Developing methods for investigating coupled enzyme systems under conditions that mimic
the cellular environment remains a significant challenge. Here we describe a biomimetic …

To generate T cells throughout adult life, the thymus must import hemopoietic progenitors from
the bone marrow via the blood. In this study, we establish that thymus settling is selective. …