Small molecule metabolites play important roles in Caenorhabditis elegans biology, but
effective approaches for identifying their chemical structures are lacking. Recent studies …

Animals coexist in commensal, pathogenic or mutualistic relationships with complex communities
of diverse organisms, including microorganisms 1 . Some bacteria produce bioactive …

Lifespan in Caenorhabditis elegans, Drosophila, and mice is regulated by conserved signaling
networks, including the insulin/insulin-like growth factor 1 (IGF-1) signaling cascade and …

Untargeted metabolomics via high-resolution mass spectrometry can reveal more than
100,000 molecular features in a single sample, many of which may represent unidentified …

Recent studies of animal metabolism have revealed large numbers of novel metabolites
that are involved in all aspects of organismal biology, but it is unclear to what extent …

The neurotransmitter serotonin plays a central role in animal behavior and physiology, and
many of its functions are regulated via evolutionarily conserved biosynthesis and …

A growing body of evidence indicates that gut microbiota influence brain function and
behaviour. However, the molecular basis of how gut bacteria modulate host nervous system …

Individuals can exhibit differences in metabolism that are caused by the interplay of genetic
background, nutritional input, microbiota and other environmental factors 1 , 2 , 3 – 4 . It is …

Nucleosides are essential cornerstones of life, and nucleoside derivatives and synthetic
analogues have important biomedical applications. Correspondingly, production of non-…

The recently discovered modular glucosides (MOGLs) form a large metabolite library
derived from combinatorial assembly of moieties from amino acid, neurotransmitter, and lipid …