Metallo-β-lactamases (MBLs) contribute to the resistance of Gram-negative bacteria to
carbapenems, last-resort antibiotics at hospital, and MBL inhibitors are urgently needed to …

Type 2 diabetes (T2D) is characterized by chronic hyperglycemia resulting from a deficiency
in insulin signaling, because of insulin resistance and/or defects in insulin secretion; it is …

The interest in brown adipose tissue (BAT) as a target to combat metabolic disease has
recently been renewed with the discovery of functional BAT in humans. In rodents, BAT can be …

Background On-pump cardiac surgery provokes a predictable perioperative myocardial
ischaemia–reperfusion injury which is associated with poor clinical outcomes. We determined …

The synthesis of a new polymer-supported coupling reagent derived from 1-hydroxybenzotriazole
is described. An aminomethylated polystyrene was functionalized by reaction with 3-…

Tuberculosis is a major disease causing every year 1.8 million deaths worldwide and represents
the leading cause of mortality resulting from a bacterial infection. Introduction in the 60's …

The side effects associated with tuberculosis therapy bring with them the risk of noncompliance
and subsequent drug resistance. Increasing the therapeutic index of antituberculosis …

We describe the synthesis of 1,2,4-oxadiazoles from carboxylic acids and amidoximes
using 2-(1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate (TBTU) as an …

Background Nonsense mutations are at the origin of many cancers and inherited genetic
diseases. The consequence of nonsense mutations is often the absence of mutant gene …

Antibiotic resistance is one of the biggest threats to human health globally. Alarmingly,
multidrug-resistant and extensively drug-resistant Mycobacterium tuberculosis have now spread …