DNA replication initiates at discrete origins along eukaryotic chromosomes. However, in most
organisms, origin firing is not efficient; a specific origin will fire in some but not all cell cycles…

Heterochromatin comprises tightly compacted repetitive regions of eukaryotic chromosomes.
The inheritance of heterochromatin through mitosis requires RNA interference (RNAi), …

INTRODUCTION Quiescence is defined as the state of a nondividing (G 0 ) cell that is still
metabolically active and able to return to the cell cycle with full viability. Quiescent cells, from …

In Saccharomyces cerevisiae, acetylation of lysine 56 (Lys-56) in the globular domain of
histone H3 plays an important role in response to genotoxic agents that interfere with DNA …

Mating‐type switching in the fission yeast Schizosaccharomyces pombe results in the
transfer of genetic information from one of the two silent cassettes (mat2P or mat3M) to the …

Centromere-binding protein B (CENP-B) is a widely conserved DNA binding factor
associated with heterochromatin and centromeric satellite repeats 1 . In fission yeast, CENP-B …

Sumoylation represents a conserved mechanism of post‐translational protein modification.
We report that Pli1p, the unique fission yeast member of the SP‐RING family, is a SUMO E3 …

Recombination is essential for the recovery of stalled/collapsed replication forks and
therefore for the maintenance of genomic stability. The situation becomes critical when the …

Schizosaccharomyces pombe is an ascomycete fungus that divides by medial fission; it is
thus commonly referred to as fission yeast, as opposed to the distantly related budding yeast …

Several accessory proteins referred to as mediators are required for the full activity of the
Rad51 (Rhp51 in fission yeast) recombinase. In this study, we analyzed in vivo functions of the …