Single-cell technologies have enabled the characterization of the tumour microenvironment
at unprecedented depth and have revealed vast cellular diversity among tumour cells and …

Single-cell technologies have revealed the complexity of the tumour immune microenvironment
with unparalleled resolution 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 – 9 . Most clinical strategies rely on …

Metastasis is the leading cause of cancer-related deaths, and obesity is associated with
increased breast cancer (BC) metastasis. Preclinical studies have shown that obese adipose …

Obesity is characterized by chronic systemic inflammation and enhances cancer metastasis
and mortality. Obesity promotes breast cancer metastasis to lung in a neutrophil-dependent …

Background Immunotherapy has revolutionized clinical outcomes for patients suffering from
lung cancer, yet relatively few patients sustain long-term durable responses. Recent studies …

Synovium is critical for maintaining joint homeostasis and may contribute to mechanobiological
responses during joint movement. We investigated mechanobiological responses of …

Glioblastoma is the most common and deadly primary brain tumor in adults. All glioblastoma
patients receiving standard-of-care surgery-radiotherapy-chemotherapy (ie, temozolomide (…

Background Pain from osteoarthritis (OA) is one of the top causes of disability worldwide,
but effective treatment is lacking. Nociceptive factors are released by activated synovial …

Receptor tyrosine kinases (RTKs) are recognized as targets of precision medicine in human
cancer upon their gene amplification or constitutive activation, resulting in increased …

High-parameter multiplex immunostaining techniques have revolutionized our ability to
image healthy and diseased tissues with unprecedented depth; however, accurate cell …