Among monoamine neurotransmitters, serotonin (5-HT) is known to play complex modulatory
roles in pain signaling mechanisms since the first reports, about forty years ago, on its …

Among receptors mediating serotonin actions in pain control, the 5-HT 7 R is of special
interest because it is expressed by primary afferent fibers and intrinsic GABAergic and …

… Benoit Michot received fellowship support from the French Ministry of Research and the
Société Française de Pharmacologie et Thérapeutique (SFPT), and Florent Viguier received …

Orofacial pain is a universal predicament, afflicting millions of individuals worldwide. Research
on the molecular mechanisms of orofacial pain has predominately focused on the role of …

Several voltage-gated sodium channels are expressed in primary sensory neurons where
they control excitability and participate in the generation and propagation of action potentials. …

Persistent pain can occur after routine dental treatments in which the dental pulp is injured.
To better understand pain chronicity after pulp injury, we assessed whether dental pulp injury …

Sensory neurons innervating the dental pulp have unique morphological and functional
characteristics compared to neurons innervating other tissues. Stimulation of dental pulp …

Introduction Pulpitis is an inflammation of dental pulp caused by bacterial proliferation near
or within pulpal tissues. In advanced stages, when the inflammation is associated with pulp …

Vasoactive intestinal peptide (VIP) is one of the neuropeptides showing the strongest up-regulation
in the nociceptive pathway after peripheral nerve injury and has been proposed to …

Background Convergent data showed that neuropathic pain has specific characteristics at
cephalic versus extra‐cephalic level, where single‐targeted drugs differentially alleviate pain. …