HBO1, an H4-specific histone acetylase, is a coactivator of the DNA replication licensing
factor Cdt1. HBO1 acetylase activity is required for licensing, because a histone acetylase (HAT)…

The origin recognition complex (ORC) binds sites from which DNA replication is initiated.
We address ORC binding selectivity in vivo by mapping ∼52,000 ORC2 binding sites …

HBO1 histone acetylase is important for DNA replication licensing. In human cells, HBO1
associates with replication origins specifically during the G1 phase of the cell cycle in a manner …

DNA methylation in mammals is a key epigenetic modification essential to normal genome
regulation and development. DNA methylation patterns are established during early …

Faithful DNA replication is essential for the maintenance of genome integrity. Incomplete
genome replication leads to DNA breaks and chromosomal rearrangements, which are causal …

Reversible acetylation of histone tails plays an important role in chromatin remodelling and
regulation of gene activity [1, 2]. While modification by histone acetyltransferase (HAT) is …

Oxidative stress induces genome-wide remodeling of the chromatin structure. In this study,
we identify Methyl-CpG Binding Protein 4 (MBD4), a multifunctional enzyme involved in DNA …

Gene regulation by AP-1 transcription factors in response to Jun N-terminal kinase (JNK)
signaling controls essential cellular processes during development and in pathological …

Adult T-cell leukemia (ATL) is an often fatal malignancy caused by infection with the complex
retrovirus, human T-cell Leukemia Virus, type 1 (HTLV-1). In ATL patient samples, the …

In response to environmental stresses, cells activate stress-response genes and inhibit
DNA replication. HBO1 histone acetylase is a coactivator both for AP-1 transcription factors …