Loss of ZnT8 function protects against diabetes by enhanced insulin secretion
A rare loss-of-function allele p.Arg138* in SLC30A8 encoding the zinc transporter 8 (ZnT8),
which is enriched in Western Finland, protects against type 2 diabetes (T2D). We recruited …
which is enriched in Western Finland, protects against type 2 diabetes (T2D). We recruited …
[HTML][HTML] Human induced pluripotent stem cells in hepatology: beyond the proof of concept
…, A Caillaud, C Gondeau, B Champon… - The American journal of …, 2014 - Elsevier
The discovery of the wide plasticity of most cell types means that it is now possible to
produce virtually any cell type in vitro. This concept, developed because of the possibility of …
produce virtually any cell type in vitro. This concept, developed because of the possibility of …
Toward personalized medicine: using cardiomyocytes differentiated from urine‐derived pluripotent stem cells to recapitulate electrophysiological characteristics of …
…, X Latypova, B Champon… - Journal of the …, 2015 - Am Heart Assoc
Background Human genetically inherited cardiac diseases have been studied mainly in
heterologous systems or animal models, independent of patients' genetic backgrounds. …
heterologous systems or animal models, independent of patients' genetic backgrounds. …
[HTML][HTML] PAX4 loss of function increases diabetes risk by altering human pancreatic endocrine cell development
…, Y Lee, J Yang, S Thaman, B Champon… - Nature …, 2023 - nature.com
The coding variant (p.Arg192His) in the transcription factor PAX4 is associated with an altered
risk for type 2 diabetes (T2D) in East Asian populations. In mice, Pax4 is essential for beta …
risk for type 2 diabetes (T2D) in East Asian populations. In mice, Pax4 is essential for beta …
mTOR-dependent proliferation defect in human ES-derived neural stem cells affected by myotonic dystrophy type 1
…, P Poydenot, A Benchoua, B Champon… - Journal of Cell …, 2013 - journals.biologists.com
Patients with myotonic dystrophy type 1 exhibit a diversity of symptoms that affect many
different organs. Among these are cognitive dysfunctions, the origin of which has remained …
different organs. Among these are cognitive dysfunctions, the origin of which has remained …
Urine-sample-derived human induced pluripotent stem cells as a model to study PCSK9-mediated autosomal dominant hypercholesterolemia
K Si-Tayeb, S Idriss, B Champon… - Disease models & …, 2016 - journals.biologists.com
Proprotein convertase subtilisin kexin type 9 (PCSK9) is a critical modulator of cholesterol
homeostasis. Whereas PCSK9 gain-of-function (GOF) mutations are associated with …
homeostasis. Whereas PCSK9 gain-of-function (GOF) mutations are associated with …
[HTML][HTML] Recurrent genomic instability of chromosome 1q in neural derivatives of human embryonic stem cells
…, M Feyeux, S Aubert, B Champon… - The Journal of …, 2012 - Am Soc Clin Investig
The evolutionary struggles from which mutants arise have been documented in almost every
living system. In this issue of the JCI, Varela and colleagues extend this list of systems to …
living system. In this issue of the JCI, Varela and colleagues extend this list of systems to …
Combined mRNA and microRNA profiling reveals that miR-148a and miR-20b control human mesenchymal stem cell phenotype via EPAS1
…, X Nissan, B Champon… - Physiological …, 2011 - journals.physiology.org
Mesenchymal stem cells (MSCs) are present in a wide variety of tissues during development
of the human embryo starting as early as the first trimester. Gene expression profiling of …
of the human embryo starting as early as the first trimester. Gene expression profiling of …
[PDF][PDF] PCSK9 regulates the NODAL signaling pathway and cellular proliferation in hiPSCs
…, A Caillaud, A Girardeau, A Rimbert, B Champon… - Stem Cell Reports, 2021 - cell.com
Proprotein convertase subtilisin kexin type 9 (PCSK9) is a key regulator of low-density
lipoprotein (LDL) cholesterol metabolism and the target of lipid-lowering drugs. PCSK9 is mainly …
lipoprotein (LDL) cholesterol metabolism and the target of lipid-lowering drugs. PCSK9 is mainly …
Global transcriptional profiling of neural and mesenchymal progenitors derived from human embryonic stem cells reveals alternative developmental signaling …
…, C Rochon-Beaucourt, B Champon… - Stem cells and …, 2011 - liebertpub.com
Human embryonic stem cells can be differentiated along different lineages, providing the
possibility of a precise analysis of genes profiles associated with specific commitments. …
possibility of a precise analysis of genes profiles associated with specific commitments. …