User profiles for Bernadette Carroll

Bernadette Carroll

Research Associate
Verified email at newcastle.ac.uk
Cited by 16246

Mitochondria are required for pro‐ageing features of the senescent phenotype

…, G Hewitt, R Hewitt, J Cole, BM Carroll… - The EMBO …, 2016 - embopress.org
Cell senescence is an important tumour suppressor mechanism and driver of ageing. Both
functions are dependent on the development of the senescent phenotype, which involves an …

[HTML][HTML] Mitochondria in cell senescence: is mitophagy the weakest link?

VI Korolchuk, S Miwa, B Carroll, T Von Zglinicki - EBioMedicine, 2017 - thelancet.com
Cell senescence is increasingly recognized as a major contributor to the loss of health and
fitness associated with aging. Senescent cells accumulate dysfunctional mitochondria; …

[PDF][PDF] Impaired autophagy in the lipid-storage disorder Niemann-Pick type C1 disease

S Sarkar, B Carroll, Y Buganim, D Maetzel, AHM Ng… - Cell reports, 2013 - cell.com
Autophagy dysfunction has been implicated in misfolded protein accumulation and cellular
toxicity in several diseases. Whether alterations in autophagy also contribute to the pathology …

[HTML][HTML] Autophagy, lipophagy and lysosomal lipid storage disorders

C Ward, N Martinez-Lopez, EG Otten, B Carroll… - … et Biophysica Acta (BBA …, 2016 - Elsevier
Autophagy is a catabolic process with an essential function in the maintenance of cellular and
tissue homeostasis. It is primarily recognised for its role in the degradation of dysfunctional …

Neutrophils induce paracrine telomere dysfunction and senescence in ROS‐dependent manner

…, S Gallage, CL Wilson, J Birch, B Carroll… - The EMBO …, 2021 - embopress.org
Cellular senescence is characterized by an irreversible cell cycle arrest as well as a pro‐inflammatory
phenotype, thought to contribute to aging and age‐related diseases. Neutrophils …

Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity

B Carroll, D Maetzel, ODK Maddocks, G Otten… - Elife, 2016 - elifesciences.org
The mammalian target of rapamycin complex 1 (mTORC1) is the key signaling hub that
regulates cellular protein homeostasis, growth, and proliferation in health and disease. As a …

Deciphering the genomic, epigenomic, and transcriptomic landscapes of pre-invasive lung cancer lesions

…, RE Hynds, M Falzon, A Capitanio, B Carroll… - Nature medicine, 2019 - nature.com
The molecular alterations that occur in cells before cancer is manifest are largely uncharted.
Lung carcinoma in situ (CIS) lesions are the pre-invasive precursor to squamous cell …

The lysosome: a crucial hub for AMPK and mTORC1 signalling

B Carroll, EA Dunlop - Biochemical Journal, 2017 - portlandpress.com
Much attention has recently been focussed on the lysosome as a signalling hub. Following
the initial discovery that localisation of the nutrient-sensitive kinase, mammalian target of …

SQSTM1/p62 mediates crosstalk between autophagy and the UPS in DNA repair

G Hewitt, B Carroll, R Sarallah, C Correia-Melo… - Autophagy, 2016 - Taylor & Francis
SQSTM1/p62 (sequestosome 1) selectively targets polyubiquitinated proteins for degradation
via macroautophagy and the proteasome. Additionally, SQSTM1 shuttles between the …

[HTML][HTML] Oxidation of SQSTM1/p62 mediates the link between redox state and protein homeostasis

B Carroll, EG Otten, D Manni, R Stefanatos… - Nature …, 2018 - nature.com
Cellular homoeostatic pathways such as macroautophagy (hereinafter autophagy) are regulated
by basic mechanisms that are conserved throughout the eukaryotic kingdom. However, …