User profiles for Bernadette Carroll
Bernadette CarrollResearch Associate Verified email at newcastle.ac.uk Cited by 16246 |
Mitochondria are required for pro‐ageing features of the senescent phenotype
…, G Hewitt, R Hewitt, J Cole, BM Carroll… - The EMBO …, 2016 - embopress.org
Cell senescence is an important tumour suppressor mechanism and driver of ageing. Both
functions are dependent on the development of the senescent phenotype, which involves an …
functions are dependent on the development of the senescent phenotype, which involves an …
[HTML][HTML] Mitochondria in cell senescence: is mitophagy the weakest link?
Cell senescence is increasingly recognized as a major contributor to the loss of health and
fitness associated with aging. Senescent cells accumulate dysfunctional mitochondria; …
fitness associated with aging. Senescent cells accumulate dysfunctional mitochondria; …
[PDF][PDF] Impaired autophagy in the lipid-storage disorder Niemann-Pick type C1 disease
Autophagy dysfunction has been implicated in misfolded protein accumulation and cellular
toxicity in several diseases. Whether alterations in autophagy also contribute to the pathology …
toxicity in several diseases. Whether alterations in autophagy also contribute to the pathology …
[HTML][HTML] Autophagy, lipophagy and lysosomal lipid storage disorders
Autophagy is a catabolic process with an essential function in the maintenance of cellular and
tissue homeostasis. It is primarily recognised for its role in the degradation of dysfunctional …
tissue homeostasis. It is primarily recognised for its role in the degradation of dysfunctional …
Neutrophils induce paracrine telomere dysfunction and senescence in ROS‐dependent manner
…, S Gallage, CL Wilson, J Birch, B Carroll… - The EMBO …, 2021 - embopress.org
Cellular senescence is characterized by an irreversible cell cycle arrest as well as a pro‐inflammatory
phenotype, thought to contribute to aging and age‐related diseases. Neutrophils …
phenotype, thought to contribute to aging and age‐related diseases. Neutrophils …
Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity
The mammalian target of rapamycin complex 1 (mTORC1) is the key signaling hub that
regulates cellular protein homeostasis, growth, and proliferation in health and disease. As a …
regulates cellular protein homeostasis, growth, and proliferation in health and disease. As a …
Deciphering the genomic, epigenomic, and transcriptomic landscapes of pre-invasive lung cancer lesions
…, RE Hynds, M Falzon, A Capitanio, B Carroll… - Nature medicine, 2019 - nature.com
The molecular alterations that occur in cells before cancer is manifest are largely uncharted.
Lung carcinoma in situ (CIS) lesions are the pre-invasive precursor to squamous cell …
Lung carcinoma in situ (CIS) lesions are the pre-invasive precursor to squamous cell …
The lysosome: a crucial hub for AMPK and mTORC1 signalling
B Carroll, EA Dunlop - Biochemical Journal, 2017 - portlandpress.com
Much attention has recently been focussed on the lysosome as a signalling hub. Following
the initial discovery that localisation of the nutrient-sensitive kinase, mammalian target of …
the initial discovery that localisation of the nutrient-sensitive kinase, mammalian target of …
SQSTM1/p62 mediates crosstalk between autophagy and the UPS in DNA repair
SQSTM1/p62 (sequestosome 1) selectively targets polyubiquitinated proteins for degradation
via macroautophagy and the proteasome. Additionally, SQSTM1 shuttles between the …
via macroautophagy and the proteasome. Additionally, SQSTM1 shuttles between the …
[HTML][HTML] Oxidation of SQSTM1/p62 mediates the link between redox state and protein homeostasis
Cellular homoeostatic pathways such as macroautophagy (hereinafter autophagy) are regulated
by basic mechanisms that are conserved throughout the eukaryotic kingdom. However, …
by basic mechanisms that are conserved throughout the eukaryotic kingdom. However, …