Optic atrophy type 1 (OPA1, MIM 165500) is a dominantly inherited optic neuropathy occurring
in 1 in 50,000 individuals 1, 2, 3 that features progressive loss in visual acuity leading, in …

Cell division cycle 25 (CDC25) phosphatases regulate key transitions between cell cycle
phases during normal cell division, and in the event of DNA damage they are key targets of the …

Mutations in the OPA1 gene are associated with autosomal dominant optic atrophy. OPA1
encodes a dynamin‐related protein orthologous to Msp1 of Schizosaccharomyces pombe and …

The CDC25 phosphatases are key regulators of normal cell division and the cell's response
to DNA damage. Earlier studies suggested non-overlapping roles for each isoform during a …

Aurora-A protein kinase, which is the product of an oncogene, is required for the assembly
of a functional mitotic apparatus and the regulation of cell ploidy. Overexpression of Aurora-A …

A unique feature of p21 that distinguishes it from the other cyclin-dependent kinase (CDK)
inhibitors is its ability to associate with the proliferating cell nuclear antigen (PCNA), an …

Activation of the cdc2 protein kinase at different stages of the cell cycle is regulated by post‐translational
modifications and interactions with cyclins. We show that in vitro translated …

This work investigates the regionalized antiproliferative effects of plasma-activated medium (PAM)
on colon adenocarcinoma multicellular tumor spheroid (MCTS), a model that mimics …

Although a major effect of p21, a cyclin-dependent kinase inhibitor, is considered to be exerted
during G 1 phase of the cell cycle, p21 gene knock-out studies suggested its involvement …

Background MultiCellular Tumor Spheroid (MCTS) mimics the organization of a tumor and
is considered as an invaluable model to study cancer cell biology and to evaluate new …