GLUT proteins are encoded by the SLC2 genes and are members of the major facilitator
superfamily of membrane transporters. Fourteen GLUT proteins are expressed in the human …

The ability to take up and metabolize glucose at the cellular level is a property shared by the
vast majority of existing organisms. Most mammalian cells import glucose by a process of …

During the last 2 years, several novel genes that encode glucose transporter-like proteins
have been identified and characterized. Because of their sequence similarity with GLUT1, …

THE amiloride-sensitive epithelial sodium channel constitutes the rate-limiting step for sodium
reabsorption in epithelial cells that line the distal part of the renal tubule, the distal colon, …

The NLRP3 inflammasome has a major role in regulating innate immunity. Deregulated
inflammasome activity is associated with several inflammatory diseases, yet little is known about …

Glucagon-like peptide 1 (GLP-1) is a hormone derived from the preproglucagon molecule
and is secreted by intestinal L cells. It is the most potent stimulator of glucose-induced insulin …

The well-characterized erythrocyte glucose transporter is also expressed in brain, adipocytes,
kidney, muscle, and certain transformed cells, but not in liver, intestine, or the islets of …

Uric acid is the metabolic end product of purine metabolism in humans. It has antioxidant
properties that may be protective but can also be pro-oxidant, depending on its chemical …

A complementary DNA for a glucagon-like peptide-1 receptor was isolated from a human
pancreatics islet cDNA library. The isolated clone encoded a protein with 90% identity to the rat …

The glucose transporter isoform GLUT2 is expressed in liver, intestine, kidney and pancreatic
islet beta cells, as well as in the central nervous system, in neurons, astrocytes and …