Here, we report a webserver for the improved SDM, used for predicting the effects of
mutations on protein stability. As a pioneering knowledge-based approach, SDM has been …

Interactions between proteins and their ligands, such as small molecules, other proteins, and
DNA, depend on specific interatomic interactions that can be classified on the basis of atom …

Many essential biological processes including cell regulation and signalling are mediated
through the assembly of protein complexes. Changes to protein-protein interaction (PPI) …

We report here a series of five chemically diverse scaffolds that have in vitro activities on
replicating and hypoxic nonreplicating bacilli by targeting the respiratory bc 1 complex in …

Mutations in the renal tumour suppressor protein, folliculin, lead to proliferative skin lesions,
lung complications and renal cell carcinoma. Folliculin has been reported to interact with …

Genome3D, available at http://www.genome3d.eu , is a new collaborative project that
integrates UK-based structural resources to provide a unique perspective on sequence–structure–…

Interest in applications of protein crystallography to medicine was evident, as the first high-resolution
structures emerged in the 50s and 60s. In Cambridge, Max Perutz and John …

Genome3D ( http://www.genome3d.eu ) is a collaborative resource that provides predicted
domain annotations and structural models for key sequences. Since introducing Genome3D …

DNA double‐strand break (DSB) repair by homologous recombination (HR) requires 3′
single‐stranded DNA (ssDNA) generation by 5′ DNA‐end resection. During meiosis, yeast …

Tuberculosis kills more than a million people annually and presents increasingly high levels
of resistance against current first line drugs. Structural information about Mycobacterium …