Multiple signatures of somatic mutations have been identified in cancer genomes. Exome
sequences of 1,001 human cancer cell lines and 577 xenografts revealed most common …

INTRODUCTION The characterization of the full spectrum of genetic variation is critical to
understanding human health and disease. Recent technological advances have made it …

About half of all cancers have somatic integrations of retrotransposons. Here, to characterize
their role in oncogenesis, we analyzed the patterns and mechanisms of somatic …

The multiple myeloma (MM) genome is heterogeneous and evolves through preclinical and
post-diagnosis phases. Here we report a catalog and hierarchy of driver lesions using …

Unlike copy number variants (CNVs), inversions remain an underexplored genetic variation
class. By integrating multiple genomic technologies, we discover 729 inversions in 41 …

Somatic rearrangements resulting in genomic structural variation drive malignant phenotypes
by altering the expression or function of cancer genes. Pan-cancer studies have revealed …

Most cancers are characterized by the somatic acquisition of genomic rearrangements
during tumour evolution that eventually drive the oncogenesis. Here, using multiplatform …

In the published version of this paper, the members of the Pan-Cancer Analysis of Whole
Genomes (PCAWG) Consortium were listed in the Supplementary Information; however, these …

Background Chimeric transcripts are commonly defined as transcripts linking two or more
different genes in the genome, and can be explained by various biological mechanisms such …

Nodal peripheral T-cell lymphoma not otherwise specified (PTCLNOS) remains a diagnosis
encompassing a heterogenous group of PTCL cases not fitting criteria for more …