User profiles for Bernd J. Wranik
 | Bernd WranikCalico Life Sciences LLC Verified email at calicolabs.com Cited by 1206 |
A new experimental platform facilitates assessment of the transcriptional and chromatin landscapes of aging yeast
10.7554/eLife.39911.001 Replicative aging of Saccharomyces cerevisiae is an established
model system for eukaryotic cellular aging. A limitation in yeast lifespan studies has been the …
model system for eukaryotic cellular aging. A limitation in yeast lifespan studies has been the …
Learning causal networks using inducible transcription factors and transcriptome‐wide time series
We present IDEA (the Induction Dynamics gene Expression Atlas), a dataset constructed by
independently inducing hundreds of transcription factors ( TF s) and measuring timecourses …
independently inducing hundreds of transcription factors ( TF s) and measuring timecourses …
[HTML][HTML] Defining the ligand specificity of the deleted in colorectal cancer (DCC) receptor
PCG Haddick, I Tom, E Luis, G Quiñones, BJ Wranik… - PloS one, 2014 - journals.plos.org
The growth and guidance of many axons in the developing nervous system require Netrin-mediated
activation of Deleted in Colorectal Cancer (DCC) and other still unknown signaling …
activation of Deleted in Colorectal Cancer (DCC) and other still unknown signaling …
[HTML][HTML] LUZ-Y, a novel platform for the mammalian cell production of full-length IgG-bispecific antibodies
BJ Wranik, EL Christensen, G Schaefer… - Journal of Biological …, 2012 - ASBMB
The ability of bispecific antibodies to simultaneously bind two unique antigens has great
clinical potential. However, most approaches utilized to generate bispecific antibodies yield …
clinical potential. However, most approaches utilized to generate bispecific antibodies yield …
[HTML][HTML] The extracellular interactome of the human adenovirus family reveals diverse strategies for immunomodulation
Viruses encode secreted and cell-surface expressed proteins essential to modulate host
immune defenses and establish productive infections. However, to date there has been no …
immune defenses and establish productive infections. However, to date there has been no …
Dual threshold optimization and network inference reveal convergent evidence from TF binding locations and TF perturbation responses
A high-confidence map of the direct, functional targets of each transcription factor (TF) requires
convergent evidence from independent sources. Two significant sources of evidence are …
convergent evidence from independent sources. Two significant sources of evidence are …
Simultaneous profiling of DNA accessibility and gene expression dynamics with ATAC-seq and RNA-seq
This chapter describes sequencing-based methods for profiling dynamic changes in DNA
accessibility and gene expression in Saccharomyces cerevisiae. Assay for transposase-…
accessibility and gene expression in Saccharomyces cerevisiae. Assay for transposase-…
The yeast lifespan machine: a microfluidic platform for automated replicative lifespan measurements
The budding yeast, Saccharomyces cerevisiae, has emerged as a model system for studying
the aging processes in eukaryotic cells. However, the full complement of tools available in …
the aging processes in eukaryotic cells. However, the full complement of tools available in …
Time-resolved genome-scale profiling reveals a causal expression network
We present an approach for inferring genome-wide regulatory causality and demonstrate its
application on a yeast dataset constructed by independently inducing hundreds of …
application on a yeast dataset constructed by independently inducing hundreds of …
Correction: Corrigendum: The extracellular interactome of the human adenovirus family reveals diverse strategies for immunomodulation
In Supplementary Fig. 3 of this Article, the sequence given for CR1B_HAdV-D19a in the
alignment shown is incorrect, and should have been identical to that listed for CR1B_HAdV-D37…
alignment shown is incorrect, and should have been identical to that listed for CR1B_HAdV-D37…