Thalidomide and its derivatives are powerful cancer therapeutics that are among the best-understood
molecular glue degraders (MGDs). These drugs selectively reprogram the E3 …

A highly convergent synthesis of the sialic acid-rich biantennary N-linked glycan found in
human glycoprotein hormones and its use in the synthesis of a fragment derived from the β-…

Background Several factors contribute to the development failure of novel pharmaceuticals,
one of the most important being adverse effects in pre-clinical and clinical studies. Early …

5510 2006 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim Angew. Chem. Int. Ed. 2006,
45, 5510–5515 embarked on a program aimed at the development of a flexible access route …

Described herein is the first total chemical synthesis of the unique α-subunit of the human
glycoprotein hormone (α-hGPH). Unlike the biologically derived glycoprotein hormones, which …

Caribbean sponge Spirastrella coccinea.[1] Unlike many other antimitotic macrolides of marine
origin, 1 does not affect tubulin polymerization in vitro but was shown to be a very potent (…

The remarkable antimitotic activity and intricate molecular architecture of the spirastrellolides
have aroused considerable interest in the synthetic community ever since their discovery, …

The human follicle-stimulating hormone (hFSH) belongs to a family of hormones responsible
for the maintenance of essential reproductive processes (gonadotropins).[1] FSH is …

In readiness for closure: To ensure optimal convergence in the projected total synthesis of
spirastrellolide F, the building block representing the southern hemisphere was prepared with …

Predicting the cellular response of compounds is a challenge central to the discovery of
new drugs. Compound biological signatures have risen as a way of representing the …