Background: Histone H3 lysine 9 (H3-K9) methylation and DNA methylation are characteristic
hallmarks of mammalian heterochromatin. H3-K9 methylation was recently shown to be a …

To identify therapeutic targets in acute myeloid leukemia (AML), we chemically interrogated
200 sequenced primary specimens. Mubritinib, a known ERBB2 inhibitor, elicited strong anti-…

A small subset of human cord blood CD34 + cells express endothelial protein C receptor (EPCR/CD201/PROCR)
when exposed to the hematopoietic stem cell (HSC) self-renewal …

Background Benefits of cord blood transplantation include low rates of relapse and chronic
graft-versus-host disease (GVHD). However, the use of cord blood is rapidly declining …

Methylation of nonhistone proteins is emerging as a regulatory mechanism to control protein
function. Set7 (Setd7) is a SET-domain-containing lysine methyltransferase that methylates …

Bone marrow haematopoietic stem cells (HSCs) are vital for lifelong maintenance of healthy
haematopoiesis. In inbred mice housed in gnotobiotic facilities, the top of the …

Accumulating evidence suggests that the regulation of gene expression by histone lysine
methylation is crucial for several biological processes. The histone lysine methyltransferase …

Chromatin modulators are emerging as attractive drug targets, given their widespread
implication in human cancers and susceptibility to pharmacological inhibition. Here we establish …

Methylation on lysine 9 of histone H3 (H3K9me) and DNA methylation play important roles
in the transcriptional silencing of specific genes and repetitive elements. Both marks are …

Acute myeloid leukemias (AML) with mutations in the NPM1 gene (NPM1c+) represent a
large AML subgroup with varying response to conventional treatment, highlighting the need to …