Background Given the projected trends in population ageing and population growth, the
number of people with dementia is expected to increase. In addition, strong evidence has …

Background Monitoring levels and trends in premature mortality is crucial to understanding
how societies can address prominent sources of early death. The Global Burden of Disease …

Background The number of individuals living with dementia is increasing, negatively affecting
families, communities, and health-care systems around the world. A successful response …

Major depression is a debilitating psychiatric illness that is typically associated with low
mood and anhedonia. Depression has a heritable component that has remained difficult to …

Since 2000, many countries have achieved considerable success in improving child survival,
but localized progress remains unclear. To inform efforts towards United Nations …

Physical and cognitive exercise may prevent or delay dementia in later life but the neural
mechanisms underlying these therapeutic benefits are largely unknown. We examined …

BACKGROUND: Accumulating evidence suggests the involvement of inflammatory
processes and cytokines in particular in the pathophysiology of major depression (MDD) and …

Alzheimer’s disease (AD) is a devastating neurodegenerative condition associated with
severe cognitive and behavioral impairments. Circadian rhythms are recurring cycles that …

Recent evidence suggests a role for tumor necrosis factor alpha (TNF) in the functioning of
the central nervous system (CNS). The aim of this work was to examine the effect of a …

Background In an era of shifting global agendas and expanded emphasis on non-communicable
diseases and injuries along with communicable diseases, sound evidence on trends …