During cell migration, the physical link between the extracellular substrate and the actin
cytoskeleton mediated by receptors of the integrin family is constantly modified. We analyzed the …

Integrins are cell–substrate adhesion molecules that provide the essential link between the
actin cytoskeleton and the extracellular matrix during cell migration. We have analyzed αVβ3-…

Cell–matrix adhesion complexes (CMACs) are foci of cellular attachment to the extracellular
matrix (ECM). This attachment, mediated by integrins and adaptor proteins, provides both …

Integrin-dependent adhesion sites consist of clustered integrins that transmit mechanical
forces and provide signaling required for cell survival and morphogenesis. Despite their …

Cell adhesion, spreading and migration require the dynamic formation and dispersal of
contacts with the extracellular matrix (ECM). In vivo, the number, availability and distribution of …

Cultured myofibroblasts are characterized by stress fibers, containing α-smooth muscle
actin (α-SMA) and by supermature focal adhesions (FAs), which are larger than FAs of α-SMA–…

Integrins are heterodimeric cell surface receptors ensuring the mechanical connection between
cells and the extracellular matrix. In addition to the anchorage of cells to the extracellular …

Mechanisms regulating thrombus stabilization remain largely unknown. Here, we report that
loss of any 1 of the Gas6 receptors (Gas6-Rs), ie, Tyro3, Axl, or Mer, or delivery of a soluble …

Integrin-dependent cell adhesions come in different shapes and serve in different cell types
for tasks ranging from cell-adhesion, migration, and the remodeling of the extracellular …

Migrating cells are polarized with a protrusive lamella at the cell front followed by the main
cell body and a retractable tail at the rear of the cell. The lamella terminates in ruffling …