How the innate and adaptive host immune system miscommunicate to worsen COVID-19
immunopathology has not been fully elucidated. Here, we perform single-cell deep-immune …

The expanding pandemic of coronavirus disease 2019 (COVID-19) requires the development
of safe, efficacious and fast-acting vaccines. Several vaccine platforms are being …

Neutrophils are recognized as important circulating effector cells in the pathophysiology of
severe coronavirus disease 2019 (COVID-19). However, their role within the inflamed lungs is …

… Bert Malengier-Devlies, Ph.D. Mieke Metzemaekers, Ph.… Malengier-Devlies,
Metzemaekers, Staels, and Vandenhaute contributed equally to this letter. Supported by grants …

COVID-19 is characterised by a broad spectrum of clinical and pathological features. Natural
killer (NK) cells play an important role in innate immune responses to viral infections. Here, …

Objectives Emerging evidence of dysregulation of the myeloid cell compartment urges
investigations on neutrophil characteristics in coronavirus disease 2019 (COVID‐19). We isolated …

Stem cells in the adult pituitary are quiescent yet show acute activation upon tissue injury.
The molecular mechanisms underlying this reaction are completely unknown. We applied …

Neutrophils are key pathogen exterminators of the innate immune system endowed with
oxidative and non-oxidative defense mechanisms. More recently, a more complex role for …

Background The molecular cause of severe congenital neutropenia (SCN) is unknown in 30%
to 50% of patients. SEC61A1 encodes the α-subunit of the Sec61 complex, which governs …

Neutrophil-depleting antibodies, such as anti-GR1 (RB6-8C5) and anti-Ly6G (1A8), are
commonly used to study the in vivo function of neutrophils in murine disease models. Anti-Ly6G …