… Fearon and Bert Vogelstein The Oncology Center Program in Human Genetics The Johns …
diverse populations with varying incidences of colon cancer (Vogelstein et al., 1988; Sasaki et …

Over the past decade, comprehensive sequencing efforts have revealed the genomic landscapes
of common forms of human cancer. For most cancer types, this landscape consists of a …

Mutations in the evolutionarily conserved codons of the p53 tumor suppressor gene are
common in diverse types of human cancer. The p53 mutational spectrum differs among cancers …

A technique for conveniently radiolabeling DNA restriction endonuclease fragments to high
specific activity is described. DNA fragments are purified from agarose gels directly by …

The revolution in cancer research can be summed up in a single sentence: cancer is, in
essence, a genetic disease. In the last decade, many important genes responsible for the …

Background Somatic mutations have the potential to encode “non-self” immunogenic antigens.
We hypothesized that tumors with a large number of somatic mutations due to mismatch-…

The adenomatous polyposis coli gene (APC) is a tumor suppressor gene that is inactivated
in most colorectal cancers. Mutations of APC cause aberrant accumulation of β-catenin, …

The ability of~ 53 to activate transcription from specific sequences suggests that genes
induced by p53 may mediate its biological role as a tumor suppressor. Using a subtractive …

Because most colorectal carcinomas appear to arise from adenomas, studies of different
stages of colorectal neoplasia may shed light on the genetic alterations involved in tumor …

The characteristics of an organism are determined by the genes expressed within it. A
method was developed, called serial analysis of gene expression (SAGE), that allows the …