The melanogenic actions of the melanocortins are mediated by the melanocortin‐1 receptor
(MC1R). MC1R is a member of the G‐protein‐coupled receptors (GPCR) superfamily …

Progressive kidney fibrosis contributes greatly to end-stage renal failure, and no specific
treatment is available to preserve organ function. During renal fibrosis, myofibroblasts …

We generated cell lines resistant to BRAF inhibitors and show that the EGF receptor (EGFR)–SRC
family kinase (SFK)–STAT3 signaling pathway was upregulated in these cells. In …

Cutaneous melanoma is epidemiologically linked to ultraviolet radiation (UVR), but the
molecular mechanisms by which UVR drives melanomagenesis remain unclear 1 , 2 . The most …

We show that in melanoma cells oncogenic BRAF, acting through MEK and the transcription
factor BRN2, downregulates the cGMP-specific phosphodiesterase PDE5A. Although …

BRAF and MEK inhibitors are effective in BRAF mutant melanoma, but most patients eventually
relapse with acquired resistance, and others present intrinsic resistance to these drugs. …

Recently, the rationale for combining targeted therapy with immunotherapy has come to light,
but our understanding of the immune response during MAPK pathway inhibitor treatment is …

Rounded-amoeboid cancer cells use actomyosin contractility driven by Rho-ROCK and JAK-STAT3
to migrate efficiently. It has been suggested that rounded-amoeboid cancer cells do …

Melanoma is a highly metastatic and lethal form of skin cancer. The protein kinase BRAF is
mutated in about 40% of melanomas, and BRAF inhibitors improve progression-free and …

The melanoma genome is dominated by ultraviolet radiation (UVR)-induced mutations. Their
relevance in disease progression is unknown. Here we classify melanomas by mutation …