Maintenance of the blood system requires balanced cell fate decisions by hematopoietic stem
and progenitor cells (HSPCs). Because cell fate choices are executed at the individual cell …

Whereas hundreds of cells in the mouse embryonic aorta transdifferentiate to hematopoietic
cells, only very few establish hematopoietic stem cell (HSC) identity at a single time point. …

10.7554/eLife.27041.001 The recent advent of methods for high-throughput single-cell
molecular profiling has catalyzed a growing sense in the scientific community that the time is ripe …

Single-cell RNA-seq quantifies biological heterogeneity across both discrete cell types and
continuous cell transitions. Partition-based graph abstraction (PAGA) provides an …

Combinatorial transcription factor (TF) interactions control cellular phenotypes and, therefore,
underpin stem cell formation, maintenance, and differentiation. Here, we report the genome…

The kinetics of the immune changes in COVID-19 across severity groups have not been
rigorously assessed. Using immunophenotyping, RNA sequencing, and serum cytokine analysis…

The development of mature blood cells from haematopoietic stem cells has long served as a
model for stem-cell research, with the haematopoietic differentiation tree being widely used …

Despite great advances in understanding the mechanisms underlying blood production,
lineage specification at the level of multipotent progenitors (MPPs) remains poorly understood. …

Activation of Janus kinase 2 (JAK2) by chromosomal translocations or point mutations is a
frequent event in haematological malignancies 1 , 2 , 3 , 4 , 5 , 6 . JAK2 is a non-receptor …

To investigate the cell-intrinsic aging mechanisms that erode the function of somatic stem cells
during aging, we have conducted a comprehensive integrated genomic analysis of young …